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这是由真人打造的‘我爱’播客。
This is a I heart podcast guaranteed human.
快乐至关重要,却也难以捉摸。现在,有一种全新而令人兴奋的方式,助你开启更快乐的生活之旅——《快乐101》。这是由我主持的新播客。如果你渴望灵感,想要最大化你的快乐,就来收听这些真诚、鼓舞人心又动人的对话吧。免费打开I Heart Radio应用,搜索“快乐101”,立即收听。《快乐101》由Hoda和Cotter主持,由CBS出品。
Joy is essential and it's also elusive but now there's a new and exciting way to start your journey toward a more joyful existence joy one zero one it's a new podcast hosted by me how to copy if you're craving inspiration to maximize your joy tune into these candid uplifting and moving on air chats open your free I heart radio app search joy one zero one and listen now joy one zero one with hoda coffee is presented by CBS.
大多数精神科医生或神经科学家都会说,我们吃的东西根本不可能影响抑郁症、双相情感障碍或精神分裂症这类疾病。
Most psychiatrists or neuroscientists will say there's no way that what we eat would play a role in something like depression, bipolar disorder or schizophrenia.
当你真正掀开这层幕布,真相简直令人毛骨悚然。
When you actually start to pull back the curtain, it's horrifying.
我们怎么知道自己的新陈代谢是健康还是不健康?
How do we know if our metabolism is healthy or unhealthy?
我今天情绪怎么样?
How's my mood?
我现在的焦虑程度如何?
How's my anxiety?
我今晚睡得怎么样?
How's my ability to sleep?
这些迹象都该引起注意,说明你的新陈代谢可能以某种方式影响了大脑。
Any of those things should be at least warning signs signs that you may have impaired metabolism somehow or another impacting your brain.
克里斯,今天能请到你真是太好了,我特别期待向你提很多问题。
Chris, it is so great to have you here today, and I'm so excited to ask you so many questions.
谢谢你抽出时间,也感谢你来到这里。
Thank you for making the time, and thanks for being here.
非常感谢你邀请我参加这个节目。
Thank you so much for having me on.
克里斯,我想从最近看过的一段内容开始聊。
Chris, I wanna start with something that I watched a part of recently.
你最近在参议院发表了演讲,我觉得说得特别有力量。
You recently addressed the Senate and I thought it was a really powerful speech you gave.
我想让听众了解一下背景。
And I just wanted the audience to get context.
那次演讲的核心观点是什么?你主要想传达什么?
What was the thesis or what was the main approach for that presentation in speech?
那次圆桌讨论的核心主题是,在美国乃至全世界,慢性病的流行趋势正在持续加剧。
The overarching theme of that roundtable discussion was that here in The United States and actually throughout the world, we have an ever increasing chronic disease epidemic.
很多人只关注肥胖和糖尿病这两个日益严重的流行病。
And so many people focus on the epidemics of obesity and diabetes.
毫无疑问,这两种病的发病率正在急剧上升。
And there's no doubt that those are skyrocketing in prevalence.
我当时去那里,是为了代表正在同步发生的心理健康危机——我们根本没法把身体健康和心理健康割裂开来,尽管很多人想这么做。
And I was there to represent the mental health epidemic that is occurring concurrently, that we really can't separate physical health and mental health, although many people want to.
随着肥胖和糖尿病的发病率不断攀升,各种精神疾病、神经发育障碍、心理问题的发病率也在同步上升,不管你怎么称呼它们。
But I think that as we have these escalating rates of obesity and diabetes, we have escalating rates of a broad range of mental illnesses, neurodevelopmental conditions, mental health conditions, mental disorders, whatever term you like.
虽然这些术语对不同人来说含义差别很大,但像自闭症、多动症、焦虑症、抑郁症、双相情感障碍、物质滥用、饮食障碍这些问题的发病率都在飙升。
Even though those things mean very different things to a lot of people, we have escalating rates of things like autism, ADHD, anxiety disorders, depression, bipolar disorder, substance use disorders, eating disorders.
这些情况遍布各种诊断类别,覆盖面非常广。
It's across the board, across a wide range of diagnoses.
归根结底,我们目前应对这些慢性病的方法根本无效,必须彻底转变思路。
And the bottom line is that what we're doing to address these chronic diseases isn't working, and we need a paradigm shift.
那世界上这些现象背后,有哪些出人意料的原因呢?
And what are some of the surprising sources of what's happening in the world?
我觉得大家都知道,社交媒体和科技发展多多少少要负一部分责任。
I think we all know that social media and the advancement of technology has some responsibility.
我们也都清楚,缺乏运动、人际疏离、长期孤独,也是原因之一。
We all know that our, you know, lack of movement and lack of connection and isolation has partly a responsibility.
但你觉得还有哪些更让人意外、更值得我们重视的因素?
But what are some of the more surprising or of the ones that you think we need to take more serious note of?
对很多人来说,一个容易被忽略的点是,导致肥胖的那些因素,其实也会影响心理健康。
I think probably for a lot of people, one of the more surprising things for mental health is that the same factors that can play a role in obesity, for example, can also play a role in mental health.
其中最常被忽视的,就是饮食和营养的作用。
And the one that gets overlooked most often is the role of diet or nutrition.
如果你去问大多数精神科医生或神经科学家,饮食对心理健康有影响吗?
If you talk to most psychiatrists or neuroscientists and ask them, does diet play a role in mental health?
他们多半会说,大概没什么关系。
Most of them will say probably not.
大脑是个极其复杂的器官,没人会认为我们吃的东西、营养,会跟注意力缺陷多动障碍、抑郁症,更别提双相情感障碍或精神分裂症这些病有什么关系。
That the brain is just a really complicated organ and there's no way that what we eat, nutrition, would play a role in something like ADHD or even depression and certainly not something like bipolar disorder or schizophrenia.
大多数心理健康领域的人都认为,这些疾病要么是遗传或生理性的,要么主要源于心理和社会因素,比如创伤、压力、社会困境,这些才是根本原因。
By and large, most people in the mental health field believe that those are either genetic biological disorders or they are largely due to psychological and social factors, trauma, stress, social adversity, and that those are the causes.
但人们往往忽略了我们每天吃进嘴里的东西——它们实际上构成了我们的大脑,影响神经递质,决定了身体每个细胞的运作方式。
But people leave out what we're putting into our mouth every day that actually becomes our brain, becomes the neurotransmitters, influences the way every cell in our body functions.
我想特别说明一下,因为这个观点对很多人来说太难接受了,他们觉得我在胡编乱造,或者根本不可能,这纯属猜测。
And I just want to point out, because this is really difficult for some people to grasp, and they think that I'm making stuff up, or they think that there's no way that can be, or this is highly speculative.
他们觉得这肯定只是推测。
This must be speculative.
我要说的是,如果你真正深入研究心理健康领域的神经科学和细胞生物学文献,就会发现,几十年来,甚至一个多世纪以来,研究人员一直在苦苦寻找精神疾病的真正成因。
And what I'm here to say is that if you actually do a deep dive into the neuroscience literature and the cell biology literature of the mental health field, researchers have been struggling for decades, actually over a century, to figure out what exactly causes mental illness.
但大量研究证据都指向同一个方向:细胞代谢异常,这种现象反复出现在各种精神健康问题中。
But numerous lines of evidence have all converged on this thing called metabolism or metabolic dysfunction in cells appears to come up again and again across a wide range of mental health conditions.
而这些相同的代谢指标或研究结果,也反复出现在肥胖、糖尿病和心血管疾病的研究里。
And those same metabolic biomarkers or studies come up for things like obesity and diabetes and cardiovascular disease.
事实上,患有这些代谢疾病的人更容易出现心理健康问题。
And in fact, people with those metabolic disorders are more likely to have mental health conditions.
而患有心理健康问题的人,也更可能患上代谢疾病。
And people with mental health conditions are more likely to have metabolic disorders.
这为我们把科学证据串联起来提供了一个方向,更重要的是,能真正帮助人们康复和恢复。
And so it's really a way to begin to put the science together, and more importantly, help people truly heal and recover sometimes.
我们现在对代谢的理解到底错在哪里?
What's wrong about our understanding of metabolism as it stands right now?
大多数人听到‘代谢’这个词,第一反应就是消耗卡路里,觉得这就是全部了。
Most people when they hear the word metabolism, they usually think about burning calories, and they think that's what it is.
他们觉得代谢就是卡路里消耗的速度,决定着你是胖还是瘦。
It's just the rate at which we burn calories, and that plays a significant role in whether we are fat or thin.
运动员对代谢的理解稍微深入一点,会关注最大摄氧量之类的代谢指标。
Athletes have a slightly more sophisticated understanding of metabolism, so they're in VO2 max and some other metrics of metabolism.
这些指标能让他们更强壮、跑得更快、耐力更好,比如能跑完马拉松,或者一百英里,想做什么都行。
And that might make them stronger or faster or have greater endurance so that they can run a marathon or they can run a 100 miles or whatever they want to do.
这些说法其实都没错。
And all of those things are in fact true.
新陈代谢确实和消耗热量有关。
Metabolism is related to burning calories.
它也和运动表现息息相关。
It is related to athletic performance.
但它远不止这些。
But it is so much more than that.
简单来说,它是生物体将食物转化为能量或细胞生长所需原料的基础过程。
A simple way to think about it is it's this foundational process that living organisms use to convert food into energy or building blocks to maintain or grow our cells.
从生物学角度看,这是定义生命体的核心特征。
From a biological stance, it's foundational in the definition of a living organism.
所以它可以说是无所不包的。
So it's kind of all encompassing.
正因如此,科学家们很难反驳我——他们往往会说,如果你这么说,那精神疾病确实应该和它有关联。
And in that way, the scientists have a hard time arguing with me because they're like, well, if you're saying that, then yeah, of course mental illnesses have to somehow be related to that.
但当我问他们营养在这一过程中扮演什么角色时,他们就答不上来了。
But I quickly stump them when I start asking them about, what about the role of nutrition in that process?
他们不得不承认,营养确实在新陈代谢中起着根本性的作用。
And they're like, well, it's undeniable that nutrition plays a foundational role in metabolism.
那你怎么能说它和精神疾病没关系呢?
So how do you think it's not related to mental illness?
这时他们几乎说不出话来,只好说:等等,你确实把我问住了。
And then they're like, almost speechless, well, wait, you've stumped me.
这不可能是对的。
That's no.
事情不可能这么简单。
It can't be that simple.
而且在
And in
现实中,是。
reality, is.
事情就是这么简单。
It is that simple.
一旦你真正理解了其中的细节,我们甚至能帮助那些患有严重精神障碍的人。
And when you really understand the details of it, we can help even people with severe crippling mental illnesses.
大多数人并不觉得饮食可能影响轻度焦虑或轻度抑郁有什么奇怪。
So most people don't have a problem thinking that diet might play a role in mild anxiety or mild depression.
很多人都能理解这一点。
Most people kind of get that.
很多家长对饮食或营养可能影响多动症也不觉得意外。
A lot of parents aren't too surprised that diet or nutrition might play a role in ADHD, for example.
我们食物里那么多糖、加工食品、人工色素,还有别的东西。
All that sugar and processed foods and artificial dyes and everything else in our food supply.
我觉得他们并不感到惊讶。
I think a lot of them aren't shocked.
他们并不觉得这可能影响孩子大脑功能的说法难以置信。
They're not in disbelief that that might play a role in the way a child's brain functions.
这些确实没错,但我现在谈的是更严重的、致残性精神疾病,比如精神分裂症和双相情感障碍。
And those things are true, but I'm also talking about the severe crippling mental illnesses, including things like schizophrenia and bipolar disorder.
所有这些疾病都包括在内。
It's all of them.
它们彼此关联,都跟新陈代谢有关。
They're all interrelated, and they all relate to metabolism.
在深入细节之前,我们先从宏观角度来看一看。
Let's look at it from a macro viewpoint before we go into the micro.
我刚开始了解这些基础内容的时候,我……
When I started learning about a very basic level of some of these things, I.
呃。
E.
加工食品里到底有什么?转基因食品里又加了什么?食物是怎么被加工处理的?
What's really in processed foods and what's really going into genetically modified foods and you know, how things are being processed.
即使只是粗略了解,我也震惊于我们居然能容忍这些东西被放进食物里。
Even at a very basic level, I was shocked to believe that we could get away with putting this stuff into food.
这真的很惊人,尤其是当我对比了美国食药监局的标准和英国的标准时——英国的要求高得多。我不是说英国就完美无缺,但当我来到美国后,发现简直连基本的规范都不到位,你甚至可以随便在包装背面写点什么,或者干脆省略一些内容,消费者根本察觉不到。
Like it's remarkable, especially when I looked at the standards of the FDA versus some of the standards in The UK, where they're a lot higher in The UK, I'm not saying they're perfect, but when I came to America, I just saw like, you didn't even, you know, it felt like you could just put anything on the back of a pack or maybe even skip a few things and people wouldn't be aware.
我们是怎么走到这一步的?
How did we get that far?
我们怎么会离‘制造真正对人有益、至少不伤害人’的东西越来越远?
Like, how did we get so far away from creating things that are actually good for people or at least not bad for them.
这种现状其实简直让人难以置信。
It's actually almost somewhat unbelievable that this is the state of affairs.
如果一个人对这个领域不太了解,他听到我们即将展开的讨论,很可能觉得这简直像在讲阴谋论。
And most a lot of people, if they're not really aware of this field, will think that the conversation that we're about to have or that we're beginning to have sounds like a conspiracy theory.
是啊。
Yeah.
怎么可能糟糕到这种地步。
Like, it can't be that bad.
政府不是在为我们把关吗?
The the government is looking out for us.
我们有食品药品监督管理局。
We have the Food and Drug Administration.
他们保证我们的食品是安全的。
They're ensuring that our food is safe.
你干嘛这么紧张?
Why are you raising alarms?
你拿这些无稽之谈吓唬人干嘛?
Why are you scaring people with this nonsense?
他们加到食品里的东西当然都是安全的,早就经过严格彻底的检测了。
Of course, everything they put in food is safe, and it's been thoroughly and rigorously tested.
那些说'是是是,没错'的人。
To those people who are saying, yeah, yeah, that's, yeah.
对啊。
Yeah.
别当阴谋论者,大家。
Don't don't be conspiracy theorists, people.
别无缘无故地吓唬我们。
Like, don't try to scare us for no reason.
我想跟你们说说一篇刚发表在《新英格兰医学杂志》上的文章,这可是美国乃至全球最有声望的医学期刊之一。
I wanna let you know about, you know, a journal article that just appeared in the New England Journal of Medicine, which is one of the most prestigious medical journals in The United States at least and arguably in the world.
这篇文章是几个月前才刊登出来的。
And it just appeared in the journal a couple of months ago.
内容是关于美国食品中化学物质和添加剂监管松懈的问题。
And it was about the lax oversight of chemicals and food additives in the food supply in The United States.
事实上,大约两年前出现过一种叫TerraFlower的人工添加剂。
And in fact, about two years ago, there was an artificial ingredient called TerraFlower.
听上去是不是特别无害?
It sounds so innocent.
对吧?
Right?
真漂亮。
It beautiful.
听起来挺美的。
It sounds beautiful.
比如‘Tera’可能是一种面粉,磨碎了用,谁知道呢?
Like, tera must be like a flour and you grind it up or who knows?
谁知道呢?
Who knows?
听着挺不错的。
It sounds lovely.
确实。
It does.
他们把这个添加到了一款新的植物肉产品里。
They added this to a new product, a beef substitute.
结果全美有四百多人因此住院,不少人还出现了肝衰竭——
And in fact, over four hundred people around The United States were hospitalized, many of them with liver failure-
医生。
Doctor.
真的吗?
Really?
医生。
Doctor.
都是因为这个产品。
Because of this product.
当FDA发现越来越多吃这种食物的人生病时,就开始展开调查。
And the FDA began an investigation when they started recognizing a lot of people who are eating this food are getting sick.
他们一开始先排查了常见的原因。
And they looked for the usual suspects initially.
检查有没有细菌感染或污染。
They looked for bacterial infections or contamination.
也排查了铅、汞之类的有毒物质是否混入食品中。
They looked for lead poisoning or mercury or something, some contaminant in the food.
但什么都没找到。
And they couldn't find anything.
他们继续深入调查。
And they continued their investigation.
后来,他们不得不开始逐项审查配料表。
And then at some point they had to start going through the ingredient list.
结果发现了一个听起来无害的东西,叫‘TerraFlower’。
And then they came across this innocent sounding thing called TerraFlower.
于是他们问:这东西到底是什么?
And they had to ask, well, what exactly is this?
他们去找了生产商,问:这到底是什么?
And they went to the manufacturer, what is it?
生产商说:哦,这是我们刚加进去的新成分。
And they said, oh, that's a new thing that we just added.
最关键的是。
And here's the kicker.
生产商自己就能宣称这成分是安全的。
The manufacturer was allowed to declare for themselves that it was safe.
美国食品药品监督管理局并不会对添加到食品中的这些新化学物质进行严格检测。
The FDA doesn't rigorously test these new chemicals that get added to our food.
他们完全依赖厂商的自我申报。
They rely on the manufacturers.
现在在美国,这全靠自觉。
It's an honor system right now in The United States.
我们被要求信任厂商的承诺?根本不可能。
It's an honor system that we are supposed to trust No way.
只要厂商自己决定要研发一种新化学物质,加进食品里,管它叫添加剂、乳化剂、食用色素,随便什么名字,都不必非得做严格的毒性测试。
The manufacturers that if they decide that they wanna create a new chemical and add it to our food and call it an additive or call it an emulsifier or a food coloring or whatever they want to do, they are not absolutely required to rigorously test it.
他们只需要自己声明一下,说这东西属于‘公认安全’,简称GRAS,连一点实际安全证据都不用提供。
Instead they can simply declare that we consider this generally recognized as safe or GRAS with no requirement of proof that it in fact is safe.
这听起来简直荒唐透顶。
And again, that sounds outrageous.
简直让人难以置信。
It sounds unbelievable.
但就在两年前,FDA刚做过一次调查,结果发现这家制造商确实添加了这种物质。
And yet the FDA just conducted an investigation two years ago and concluded that this manufacturer included that stuff.
当你真正揭开这层幕布,简直令人毛骨悚然。
When you actually start to pull back the curtain, it's horrifying.
真的太吓人了。
It's horrifying.
美国食品中大约有一万种化学物质,其中很多根本没经过严格的安全检测,连对肝脏有没有伤害都没查清楚,更别说——最让人害怕的是——
About 10,000 chemicals are in The US food supply, and many of them have not been rigorously tested for safety, like liver failure safety, let alone and here's the kicker, and here's the really kind of terrifying thing.
这些化学物质到底会对人体的新陈代谢或大脑产生什么影响?
Let alone, what impact do these molecules have on human metabolism or the human brain?
没人知道。
We don't know.
根本没人去问这个问题,也没人愿意做这项研究。
No one knows because nobody's bothered to ask that question and nobody's bothered to do the research.
所以,这种缺乏监管的食品添加行为,很可能就是我们如今慢性病泛滥的罪魁祸首。
So that becomes a likely culprit in this chronic disease epidemic that we're allowing manufacturers to just put all sorts of stuff into our food without testing it.
这无疑是导致我们慢性病泛滥的明显原因之一。
And it's certainly one of the lower hanging obvious choices in terms of what might be driving our chronic disease epidemic.
从这个角度看,真让人震惊——我们每天往身体里塞东西,却默认它们都经过了安全测试,或者至少希望有人替我们考虑过它们是否健康。
It's remarkable when you hear it from that perspective of the idea that we're all putting things into our body, trusting that they've been tested or at least being hopeful that someone's thought about them being good for us.
不仅没经过测试,这些成分还被随意添加进食品,几乎没经过任何前期研究或审查。
And not only have they not been tested, they've been added in without much prior thought or research or checking.
这太难了,你看现在这么多人在挣扎,人们自然会觉得自己该负责,觉得‘我得改改了’‘我得减肥’‘我得增肌’,可这整个系统,好像从一开始就和他们作对。
And it's so hard because you look at so many people who are struggling today and people naturally, I think put, you know, take responsibility and they think, God, I need to be better or I need to lose weight or I need to build muscle or whatever it is that they want to do, but it almost seems like the system's set up against them.
我们从小就被训练着吃这些产品,化学物质早就渗进身体了,想改掉这些习惯,当然更难。
We've been conditioned and hardwired since we've been young eating these products, the chemicals have got into our bodies and of course it's harder to break that habit.
所以,我对每一个正在为健康发愁的人,都充满理解和同情,因为这并不全是他们的错。
So I feel so much empathy and compassion for anyone who is struggling right now with their health because it's partly not their fault.
完全正确。
100%.
我觉得绝大多数情况下,甚至可以说几乎全部情况,都不是他们的错。
I actually think in most cases, in almost all cases, it's not their fault.
对。
Mhmm.
他们小时候,父母给他们吃的东西,都是自以为健康的食物。
That they were children at some point, and their parents were feeding them what they thought was healthy food.
当时美国膳食指南委员会告诉他们哪些是健康食品,现在还是在告诉人们这些是健康食品。
And what they are were being told by the US dietary guideline committee are healthy foods, and what they're still being told are healthy foods.
到目前为止,美国膳食指南根本没提到超加工食品。
You know, The US dietary guidelines to date don't mention ultra processed foods.
也没提这些人工添加剂,因为大家默认它们无关紧要。
They don't mention all of these artificial ingredients because the assumption is they don't matter.
大家的假设就是,只要保证摄入足够热量就行。
The assumption is just make sure you get enough calories.
尽量减少饱和脂肪。
Try to minimize saturated fat.
糖分稍微控制一下,别超过总热量的10%,但这个量其实还是很高。
Maybe minimize sugar somewhat, less than 10% of your calories from sugar, which is a lot still.
是的
Yeah.
百分之十
1010%
从糖分中摄取这么多营养,糖的摄入量实在太高了。
of your nutrition from sugar is a lot of sugar.
但他们根本没提这些其他成分对人类健康的影响。
But they don't even mention the impact of these other substances on human health.
不过替他们说句公道话,三十年前,几乎没人意识到这些问题。
And in their defense, I think thirty years ago, nobody seemed to be aware of much of this.
当时真正认真研究这些、彻底理解其本质的人少之又少。
There were very few people, if any, who were really rigorously researching this and really fully understood what is this.
但现在我们已经有了大量证据——流行病学数据、基础科学研究、动物实验,各种渠道的证据都一致表明,这些食物对我们有害。
But now we have more than ample evidence, epidemiological evidence, basic science evidence, animal studies, all sorts of things, numerous lines of evidence to all support this conclusion that these foods are bad for us.
我想再次强调的是,它们对人类健康的影响是全方位的。
And I think, again, the thing that I really want to drill home for people is that they affect human health broadly.
是的,它们与超重或肥胖有关。
Yes, they play a role in overweight or obesity.
是的,它们与心脏病有关。
Yes, they play a role in heart disease.
是的,它们会影响糖尿病和血糖水平。
Yes, they play a role in diabetes and blood sugars.
但别忘了大脑。
But let's not forget the brain.
这才是棘手的地方。
That's the tricky thing.
因为我想说的是,就像吃这些食物或吃得太多会损害心脏,导致病理性的变化,甚至可能引发心脏病发作一样。
Because what I'm arguing is that in the same way that eating these foods or too much of these foods can drive your heart to actually become pathologically compromised to the point of you potentially having a heart attack.
它们也会让肝脏堆积脂肪,影响其正常功能。
It can cause your liver to fill up with fat, which impairs its function.
还可能导致肾脏问题。
It can cause kidney problems.
它还会导致免疫系统功能紊乱。
It can cause immune system dysfunction.
就像这些器官一个个开始出问题一样,最让人困惑的是大脑。
In the way that all of those different organs are beginning to malfunction, the confusing thing to a lot of people is the brain.
因为大脑出问题时,通常都很隐蔽。
Because when the brain malfunctions, it's usually subtle.
对大多数人来说,最早的表现是脑子发懵、缺乏动力、情绪低落、轻微焦虑,或者注意力不集中。
And it starts for most people in the form of things like brain fog, or a lack of motivation, or depressed mood, or mild anxiety symptoms, or inattention.
这些症状其实很多人都经历过。
Like those are the types of things that most people experience.
而这些症状在当今社会简直随处可见。
And those of course are ubiquitous symptoms today in society.
比如倦怠感的发病率,现在达到了历史最高水平。
When you look at the rates of burnout, for example, We have record rates of burnout.
但大多数人根本不会把倦怠和代谢健康联系起来,更别提和每天吃的东西挂钩了。
And most people would never even associate burnout with their metabolic health, let alone with what they're putting into their mouth every day.
我并不是想完全开脱职场的责任。
And what I'm saying, I'm not trying to exonerate the workplace completely.
没错,我们很多人都工作过度。
So yes, many of us are overworked.
没错,我们很多人都在连轴转。
Yes, many of us are going 20 fourseven.
没错,现在的上司们往往希望我们半夜还回邮件,因为公司出了什么紧急状况之类的。
Yes, many of our bosses now expect us to, you know, respond to emails at midnight because there's a crisis at work or whatever.
这确实让人压力巨大。
And yes, that is extraordinarily stressful.
这无疑在加剧倦怠感。
That is absolutely playing a role in burnout.
但我们的大脑本身的身体健康也同样关键。
But so too is the actual physical health of our brain.
我之所以这么肯定,是因为我接触过无数人,他们通过调整饮食、开始锻炼、重视睡眠,或者大幅减少看屏幕的时间,都得到了改善。
And the reason I can say that so confidently is because I've had numerous, countless people who have done things like change their diet or begun exercising or prioritize sleep or just taken themselves off of their screen for so much.
他们的
And their
倦怠感就消失了。
burnout evaporates.
他们的工作环境一点没变,但对它的承受力却大大提升了。
Their work situation doesn't change one bit, but their tolerance for it changes immensely.
突然间,他们从那种觉得自己跟不上节奏的人,
And all of a sudden, they go from somebody who feels like, I can't keep up.
觉得自己跟不上节奏,
I can't keep up.
总觉得不够好,
I'm never good enough.
实在干不了这么多活,
I just can't do this much work.
变成了疑惑:我以前怎么会被这些事压得喘不过气?
They're being too hard on me to why was I so stressed by this?
这其实没那么难。
This actually isn't that difficult.
我很有韧性。
I'm resilient.
我很聪明。
I'm smart.
我效率很高。
I'm efficient.
我的脑子现在特别清醒。
My brain is on fire.
我的脑子在想:我居然一个小时就把这份报告做完了。
My brain is like, I just got that report done in one hour.
两个月前,我做这份报告可花了整整两天。
And two months ago, it took me two days to do that report.
难怪我之前那么累。
No wonder I was so burned out.
是的
Yeah.
我花两天才做完那份报告,其实本来一个小时就能搞定。
Took me two days to do the report when it really should have only taken me an hour to do it.
当你让人们的思维重新运转起来,全新的可能性就打开了。
And so when you bring people's brains back online, a whole new world opens up.
对
Yeah.
说实话,你这么说特别打动我,因为对我们很多人来说,都很清楚,短期内工作量根本不可能减少。
You know, hearing that resonates so strongly for me because I feel that for so many of us, we know that it's very unlikely there'll be a day soon enough that our workload will diminish.
对吧?
Right?
如果你总盼着哪天工作能轻松点,压力其实就来自知道这一天根本不会来。
If you're waiting for that day for your work to reduce and the workload to go down, kind of that's what stresses us out is knowing that that day isn't gonna come.
而你刚才说的这一点很关键——当你去调整这些方面,你的承受力会提升,应对压力的能力会增强,韧性也会越来越强。
And this idea of what you just said that actually, but when you work on all these things, your tolerance grows and your ability to deal with that level of stress and pressure grows and your resilience grows.
这让我想起几年前,甚至更久以前,我曾经面临一个选择,而且我当时非常清楚地意识到了这个选择。
And it reminds me a couple of years back, maybe even a bit longer now, I remember I had a choice and I saw the choice very consciously.
我要么就得放慢节奏,要么就得大幅提升自己的健康状况,因为那段时间我工作得比以往任何时候都多。
I either had to slow down or I had to up level my health because I was working more than ever.
我工作得比以往任何时候都拼命。
I was working harder than ever.
但我不想放慢脚步,因为我真的很热爱我所做的事情。
And I didn't want to slow down because I love what I do.
我非常感恩能做这份工作。
And I'm really grateful I get to do what I do.
但我明白,如果我不在睡眠、饮食、冥想和锻炼这些方面彻底改善健康,我就根本撑不下去。
But I saw that if I didn't improve my health drastically taking into account sleep, diet, meditation, working out exercise, then there was no way I could keep up.
再这样下去,只会越来越糟。
It was gonna be downhill.
虽然我还没做到完美,现在也还在不断调整、努力提升每一个方面,但当我做出这些改变后,我发现自己身体和心智的承受能力,远远超出了我以前的想象。
And having made all those changes, not that I've perfected them and I'm still in the process of always iterating and trying to get better at all of them and strengthen different parts, but I found myself having a much greater capacity than I ever imagined of what my body and mind are capable of doing.
而且我真的挺感恩的,能做自己热爱的事,真的很幸运。
And again, I'm grateful I am lucky I get to do what I love.
这一点确实至关重要,带来了巨大的不同。
So there's that element for sure that makes a big difference.
但你说得对,我的抗压能力和承受工作量的耐力,比以前强太多了。
But what you're saying is so true that my resilience and my tolerance for the amount of what I do is far greater than it would have been.
我不认同那种虚假的幻想,说什么总有一天你只需要完成一半的报告。
And so I love that we're not living in this fake land of, oh yeah, there'll be a day when, you know, you'll only have to do 50% of that report.
不可能。
No.
报告你还是得做完,只是它不会再让你那么焦虑了。
You're still gonna have to do that report, but maybe it won't stress you out as much.
从某种角度来说,这其实说的是一件再明显不过的事。
In one way, this comes down to something that seems so obvious.
你一说出来,大家都会点头说对。
When you say it, it's like everybody's like, yeah.
这种话我们听得太多了。
We've heard that a million times.
太老生常谈了。
That's so cliche.
说来说去也没什么实际意义。
Like, it doesn't really mean anything.
这其实就是自我照顾。
And that is self care.
你越是拼命工作,就越该抽时间冥想,或者好好做顿营养餐,而不是随手拿点加工过度的垃圾食品对付一下。
That if you're working really hard, it's actually even more important that you take time out to meditate or to prepare a healthful meal instead of grabbing junk food already prepared, ultra processed.
你更该保证充足的睡眠。
It's even more important that you take enough time to get adequate sleep.
哪怕你觉得像在跑步机上狂奔,根本停不下来。
Even though you feel like you're on a treadmill and you can't keep up.
不睡觉,第二天你的大脑效率就会直接下滑。
By not sleeping, you're slowing down your brain capacity the next day.
结果你工作越落越多,只好熬夜更晚,拼命想追上进度。
And now you get even further behind in your work, and then you feel the need to stay up even later trying to catch up.
现在你更加缺觉,大脑根本转不动了。
And now you're even more sleep deprived, and now your brain is really not firing on all cylinders.
所以大家总爱说一句口号:要自我照顾。
So the sound bite recommendation is self care.
人人都说:说得对。
And everybody's like, yeah.
这话我们听过上百万遍了。
We've heard that a million times.
这话根本没用。
That's so worthless.
别跟我们说些早就听腻的老生常谈。
Don't tell us something we haven't heard.
可还是有太多美国人,还有世界各地的人,深陷这种恶性循环,就是不肯这么做。
And yet so many Americans and people around the world are getting trapped in these vicious cycles where they're not doing it.
对
Mhmm.
对
Mhmm.
我觉得,当我们真正留出足够的时间,其实根本不是在‘花时间’放慢脚步。
I think that when we take enough time, it's not even take time to slow down.
因为我特别认同你刚才说的。
Because I love what you just said.
我希望人们能充满活力地生活。
I want people to live life with vigor.
我希望人们能拥有热情。
I want people to have passion.
世界上有那么多问题。
There are so many problems in the world.
我们需要有人充满热情地站出来,挺身而出。
We need people to be passionate and step up and be there.
在你的事业上全力以赴。
Be there for your career.
为别人挺身而出。
Be there for other people.
在家人身边陪伴支持。
Be there for your family.
对朋友不离不弃。
Be there for your friends.
这意味着要行动起来。
That means doing stuff.
不是瘫在沙发上一整晚刷剧。
It doesn't mean slowing down and watching Netflix all night.
要行动,但也要注意好好照顾自己,让这股热情能持续燃烧下去。
It means doing stuff, but make sure that you're doing enough self care so that that engine can keep running and so that that passion remains.
你觉得那天在场的人里,有没有真正能带来改变的关键人物听到了你的话?
Do you feel the right people were in the room that day who heard you that can make a change?
从宏观层面来看,你觉得改变应该从哪里开始?
Where do you feel the change from a macro level needs to come from?
你认为我们现在正处于即将发生这种转变的阶段吗?还是你觉得不太有希望?
And do you think we're in a phase where we're gonna go into that change, or do you not feel hopeful?
这事儿最后变得特别复杂,尤其是涉及政治方面,毕竟我们刚经历过一场选举。
It ends up getting really complicated, especially in terms of the politics because, you know, we had an election.
我跟几位记者聊过,他们说那次圆桌讨论真的点燃了‘让美国再次健康’这个运动,让它迅速传播开来。
And I've spoken with a couple of reporters who actually said that roundtable discussion really put the Make America Healthy Again movement on fire and really allowed it to spread.
现实是,我们即将迎来一个新的政府。
The reality is that we have a new incoming administration.
我想明确说一句,我完全理解这场选举有多么分裂,也明白有些人对选举结果根本无法接受。
I wanna just say for the record, I fully recognize how politically divisive the election has been, how some people are not at all happy about the election results.
有些人担心接下来会发生什么,感到害怕。
Some people are terrified what's gonna happen.
有些人则非常愤怒。
Some people are angry.
我一直在跟这些人交流。
I'm hearing from those people all the time.
但我还是想说,机会也同样存在。
And yet I wanna say that there are opportunities as well.
我觉得现在,尤其是在医疗保健和国立卫生研究院方面,即将迎来一些重大的变革。
And I think that right now, especially in health care and the National Institutes of Health, that there are going to be some disruptive changes coming.
最终是好是坏,还得看时间怎么发展。
Time will tell whether that ends up being a good thing or a bad thing.
我最期待的是,一场全国性的对话已经开始了。
And the thing that I'm most hopeful about is that a national conversation has begun.
已经过去了。
Been gone.
是的。
Yeah.
就在前几天,我们刚开了场参议院听证会,主要是民主党人参加的。
Just the other day, we had senate hearings largely with Democrats.
我们还听到了像科里·布克和伯尼·桑德斯这样的坚定自由派民主党人发言,他们谈论的内容,竟然和我们之前在保守派共和党圆桌会上听到的完全一样。
And we heard from staunch liberal Democrats like Cory Booker and Bernie Sanders and others who were having the exact same conversations that we had in that conservative Republican Senate roundtable discussion.
我觉得这让人充满希望,尽管政治对立激烈,尽管我们会在很多问题上意见不合——当然,有人偶尔会问我:你站哪一边?
And I think that is hopeful because despite the political animosities and despite all the things that we are going to disagree on, make no mistake, people sometimes do ask me, like, what side do you take?
我哪一边都不站。
I I don't take a side.
我是个普通人,对很多问题都有复杂的想法。
I'm a human being with complex perspectives on a lot of different issues.
我不觉得这世界上有哪个人,是我完全同意他所有观点的。
I don't think there's one human being on the planet that I would say I agree on everything with.
所以这么做挺明智的。
So It's probably wise.
对。
Yeah.
所以我会对各种问题有自己的看法,有时候还相当强烈。
So I am going to have my own, sometimes very strong opinions on different issues.
但我们都同意的一点是,现在正面临一场慢性病的流行,主要就是代谢类疾病和心理疾病,我们必须把相关的科学研究整合起来,是时候真正采取行动了。
But what we can all agree on is that there is this chronic disease epidemic, that it is primarily metabolic health disorders and mental health disorders, and we need to put together that science, and once and for all, we need to start doing something about it.
这还包括要直面那些在其中起主要作用的企业腐败行为。
And that includes taking on corporate corruption that is largely playing a role in this.
具体来说,这到底意味着什么?
Concretely, what does that mean?
回到我们刚才聊过的内容,制造商不应该在没有经过严格检测的情况下,就把任何新化学物质添加到销往美国的食品里。
To come back to what we just talked about a little bit ago, manufacturers should not be allowed to introduce brand new chemicals into food that is sold in The United States without rigorous testing.
到底是谁会觉得这种做法是合理的?
Why on earth does anybody think that's a good idea?
我们已经有很多未经检测的化学物质了,要追上它们都来不及,为什么还要再添新的?
We have more than enough chemicals to choose from that are already not tested, So we got a lot of work to do to try to catch up, but why do we need even more new ones?
我们不需要。
We don't.
当然。
For sure.
没错。
For sure.
再往微观层面说,我们怎么判断自己的新陈代谢是健康还是不健康?
Switching to the more micro, how do we know if our metabolism's healthy or unhealthy?
身体会有什么感觉?
How do we feel it?
医生。
Doctor.
我特别关注的是大脑方面的影响。
So I'm really focused on the brain effects.
可惜的是,目前还没有能让普通人直接去做的客观检测手段。
And unfortunately there are not objective tests that people can go out and get.
所以你只能靠自己主观地去观察和思考。
So you really do have to just subjectively think through.
对。
Mhmm.
我的情绪怎么样?
How's my mood?
我的焦虑感如何?
How's my anxiety?
我睡得还好吗?
How's my ability to sleep?
我使用物质的情况如何?
How's my use of substances?
我的人际关系怎么样?
How are my relationships?
我平时怎么跟别人相处?
How do I interact with others?
我有没有突然出现恐慌发作?
Am I having panic attacks?
这些方面如果无缘无故地出问题,至少该引起注意,说明你的新陈代谢可能在以某种方式影响大脑。
Of those things, especially when they're occurring for no clear reason, should be at least warning signs that you may have impaired metabolism somehow or another impacting your brain.
好消息是,我们其实有一些具体的生物标志物可以参考,这些通常就是所谓的代谢综合征指标。
The good news is that there are some concrete biomarkers that we can all use, and those are usually the biomarkers for what we call metabolic syndrome.
这些指标包括低密度脂蛋白胆固醇偏低、甘油三酯偏高、血糖偏高——也就是前期糖尿病或胰岛素抵抗,不管怎么叫,还有高血压,以及腹部肥胖或腹部脂肪过多。
And those biomarkers include low HDL cholesterol, high triglycerides, high blood sugar, so prediabetes, insulin resistance, whatever it gets called, high blood pressure, and then abdominal obesity or extra abdominal fat.
如果你还不知道这一点,可能会很震惊:目前有93%的美国人至少存在其中一项异常。
The shocking news for any of your listeners who don't know this is that ninety three percent of Americans currently have one or more abnormalities Wow.
就在这些生物标志物当中。
Among those biomarkers.
先不谈大脑的问题。
Leaving the brain out of it.
要想被认定为代谢健康,你必须这五项指标一项都没有,但目前只有7%的美国成年人符合这个标准。
In order to be considered metabolically healthy, you would have to have none of those five biomarkers, and only seven percent of American adults currently gets that.
所以很遗憾,这确实是一场代谢和心理健康双重失调的流行病。
So unfortunately, this really is an epidemic, a chronic disease epidemic of metabolic and mental health dysfunction.
假设有人正经历你刚才提到的那些情况。
Let's say people are experiencing those things as you mentioned.
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情绪波动、脑子发懵、精力不足,这些他们都遇到了。
So fluctuation in mood, they're experiencing brain fog, they're experiencing low energy.
那他们该从哪里开始呢?
Where should they start?
我觉得普通人其实可以自己先从一些基本的做法入手。
The basics that I think people can really do on their own.
我就先从这儿说起。
And I'll start there.
我得先说明一下,我是个精神科医生,主要治疗精神分裂症和双相情感障碍这类疾病。
I just wanna say as a caveat, because I'm a psychiatrist who treats like schizophrenia and bipolar.
所以那些孩子的家长听了可能会说:别跟我讲这些空话。
And so those those parents are listening to me like, don't give me this
对。
Yeah.
这些都没用。
Fluff.
别跟我来这套虚的,咱们直接说重点
Don't like, me the real Let's go
这种话题我们经常聊。
to that often.
对。
Yeah.
这个我们后面会谈到。
We can get to that.
但对于绝大多数成年人,甚至孩子来说,我觉得可以归结为生活方式医学的六大支柱。
But for the overwhelming majority of adults and even children, I would say it breaks into the six pillars of what we call lifestyle medicine.
我们会分别来看饮食与营养、运动、睡眠、减少或避免有害物质的使用,以及冥想或正念等减压方法。
And so we're gonna look at diet and nutrition, movement or exercise, sleep, minimizing or reducing harmful substances if you happen to use any of them, stress reduction practices like meditation or mindfulness.
通常第六点人们会提到人际关系,而且是有意为之。
And then usually that sixth bucket, people will talk about relationships on purpose.
但我更愿意把它扩展为人生目标。
I like to broaden it to purpose.
我认为这是其中一项主要作用。
And I think that's one of the primary roles.
它当然不是唯一的,但确实是关系所发挥的主要作用之一。
It's certainly not the only, but one of the primary roles that relationships serve.
所以我通常会说,关系或者说是人生目标。
So I I kinda say relationships slash purpose.
你们的听众早就对人生目标、人际关系、冥想和正念很熟悉了。
So all of your listeners are already all over purpose and relationships and meditation and mindfulness.
减少有害物质的使用。
Reducing harmful substances.
这一点很明显。
It's pretty obvious.
我说的是酒精、大麻、吸烟、电子烟这类东西。
I'm talking about alcohol, marijuana, smoking, vaping, those kind of things.
这些对身体都没什么好处。
So those are not good for you.
不管你听谁说的,都说 vaping 对你有好处,其实根本不是这么回事
No no matter what you've heard, no matter who said this vape is really good for you, it's really
没错
not
一点都不好
good
那为什么不好呢?
Why is for it no good?
它到底对身体有什么影响?
What's it doing?
这要看 vape 里头含什么成分,但我们的身体根本不是设计来把化学物质吸进肺里的
So it depends on what's in the vape, but we are actually not designed to inhale chemicals into our lungs.
有意思
Interesting.
肺部本来就不该接触这些 vape 里的化学物质
Our lungs are not supposed to have this vape chemical in them.
而且你知道,确实出现过一些极端案例,有人因为使用了可能被污染的电子烟,引发了危及生命的肺炎样症状。
And, you know, there have been extreme examples where people actually develop life threatening kinda pneumonia type situations from possibly contaminated vapes.
但长期研究显示,使用电子烟的人更容易出现与这一领域相关的健康问题。
But we know from long term studies that people who are vaping are more likely to still have health conditions on that specific topic.
如果有人一直在吸传统香烟,又戒不掉,那么用电子烟代替会不会好一点?
If somebody is smoking tobacco, and they can't stop smoking tobacco, is vaping better for them?
是的,对这些人来说,电子烟确实更安全一些。
Yes, it is better for them.
如果你正吸香烟,实在戒不掉,但愿意改用电子烟代替,那不妨试试看,先换成电子烟。
So if you're moving from smoking cigarettes, you cannot quit, but maybe you could just vape instead of smoking cigarettes, then go ahead, start vaping.
但你终究得戒掉电子烟,因为电子烟本身也不健康。
But then at some point, I want you to stop vaping because vaping's not healthy for you.
对。
Right.
而且具体还要看里面含的是什么物质,因为有些人是在用电子烟吸大麻成分。
And then it really depends on the substance that it's in it because people are vaping THC.
他们在用电子烟吸尼古丁。
They're vaping nicotine.
他们吸的东西五花八门。
They're vaping all sorts of things.
最糟糕的是,即使人们从吸烟转为吸尼古丁电子烟,尼古丁的含量也往往高得离谱,远超以前吸烟时的水平。
And the the tragic news is even when people switch from smoking cigarettes to vaping nicotine, more often than not, the nicotine concentrations are stratospheric compared to what they were smoking.
结果反而让他们对尼古丁的依赖比以前更严重了。
And so they end up getting even more addicted to nicotine than they ever had been.
现在他们根本戒不掉了。
And now they really can't stop.
医生。
Doctor.
大麻对大脑有什么影响?
What's marijuana doing to the brain?
大麻的成分其实非常复杂。
Marijuana actually has a lot of constituents.
如果你说的是整个植物,那里面含有多种化学物质。
If you're talking about the whole plant, it's got a lot of different chemicals in it.
有些可能是中性的。
Some that might be neutral.
有些人认为其中一些可能有益。
Some will argue might be beneficial.
CBD是最常被提及、可能对人有好处的成分。
CBD is the most commonly touted one that might have some benefits for people.
我们可以明确地说,THC对人脑有害。
I think what we can unequivocally say is that THC is bad for the human brain.
THC会引发多种作用。
So THC does a lot of different things.
它在我们大脑和身体的各个部位与受体发生作用。
It's interacting with these receptors throughout our brain and body.
它会让心率加快。
It makes your heart rate go up.
我的一些科学研究核心在于,它会损害线粒体的功能。
You know, central to some of my science work is it can impair mitochondrial function.
这些存在于细胞里的微小结构叫线粒体,它会影响它们正常运作的能力。
So these tiny things in our cells called mitochondria, it can impair their ability to function.
归根结底,我们清楚地知道,大量吸食大麻的人会出现认知功能下降。
And at the end of the day, the end result is that we know that people who smoke a lot of marijuana will have cognitive impairment.
他们的动力也会明显减弱。
They will have impairment in motivation.
不过,对大多数人来说,这应该并不意外。
Now this is probably not a shock to most people.
想象一下,一个少年整天待在父母家的地下室里打游戏、吸大麻。
So imagine the teenage boy in his parents basement playing video games all day smoking weed.
他没什么干劲,还一副无所谓的样子。
He's less than motivated, and he's chillaxed about it.
他根本不介意自己什么都没做。
He's not bothered that he's not doing a lot.
他根本不介意自己的大脑状态不好,因为他觉得挺放松的。
He's not bothered that his brain doesn't work all that great because he's relaxed.
这样过日子可不怎么样,更谈不上在生活中找到目标、维系关系,或者做其他任何有意义的事。
Not a great way to go through life, and certainly not a great way to have purpose in your life and relationships and everything else.
但更重要的是,长期下来它会损害大脑功能。
But more importantly, it can impair brain function over time.
我们最明显的证据是,THC会增加患精神病的风险。
And the most striking evidence that we have is that THC can increase risk for psychosis.
这一点在动物实验中已经得到了证实。
And we know that from animal models.
你可以让动物别无选择,只能接受某种物质。
So you can take an animal that has no choice in whether they're getting something or not.
我们给它们注射THC,它们就会出现严重的脑部问题,比如精神障碍。
We can give them THC, and they can develop severe brain conditions, like conditions.
我们还有很多人类数据,尤其是流行病学研究,毕竟我们不可能拿一千个孩子做随机对照试验,让一半每天吸大麻,另一半完全不吸。
We have a lot of human data, more epidemiological data, because we can't do a randomized controlled trial of a thousand kids and have half of them smoke marijuana every day and half of them not.
伦理委员会绝不会批准这样的实验。
Would never be approved by an ethics board.
所以我们只能观察那些吸烟和不吸烟的人,看看前者是否更容易出现精神病性障碍。
So instead we have to look at people who are smoking versus not smoking and seeing are they more likely to develop psychotic disorders.
事实上,他们患上类似精神分裂症或双相情感障碍的风险,大概是不吸烟者的四倍。
And in fact, it seems that they're probably about four times more likely to develop something like schizophrenia or bipolar disorder than people who don't.
所以,大麻并不好。
So marijuana, not good.
酒精也是类似的情况,对大脑不好,对代谢健康也没好处。
Alcohol, similar kind of story, not good for your brain, not good for metabolic health.
我想大多数人应该都知道运动的建议。
You know, I think most people probably know the exercise recommendation.
多动动。
Move.
尽量增加肌肉量。
Try to build muscle.
就算你现在是个沙发土豆,特别超重,随便做点什么也好。
Like, even if you're a couch potato right now and really overweight, just anything.
在客厅里走走。
Walk around your living room.
做几个深蹲。
Do some squats.
跳一两下开合跳。
Do one or two jumping jacks.
随便做什么都行。
Like, anything.
先从哪儿开始都行。
Just start somewhere.
我还会建议大家尽量到户外去活动。
And then I would probably encourage people to try to get outside.
如果刚开始运动,就试着到户外,因为那时候你其实是在同时获得好几种好处。
If they're really new to movement, try to go outside because you're getting, like, multiple interventions at that point.
你离开屏幕了,所以别出门还把手机举在脸前面。
You're getting away from a screen, so don't walk outside with your cell phone in front of your face.
出去走走,好好感受大自然。
Walk outside and just enjoy nature.
试着留心一下你周围的环境。
Like, try to be mindful of your environment.
就算在城市里,你也能抬头看看天空、云彩,或者留意周围的树木,哪怕是街角的小公园也好。
Even if you're in the city, you can still look at the sky and see the clouds or look at what trees might be around, or any little corner park or something.
对。
Yeah.
这样你就同时获得了阳光、接触自然,还练了正念。
So that can become an intervention where now you're getting some sunlight, now you're out in nature, now you're practicing some mindfulness.
走路的时候,你暂时远离了屏幕,给大脑一点喘息的空间。
As you're moving your legs and walking around, you're getting away from screens for at least a little bit of time, and that can give your brain a break.
从简单的活动到练CrossFit,运动的方式多得很。
So lots of ways to do movement all the way up to do CrossFit.
去跑个马拉松吧。
Go run a marathon.
想做什么就做什么吧。
Do like like what whatever you wanna do.
是的。
Yeah.
对。
Yeah.
至于饮食,说实话,这是最复杂的话题。
And then nutrition honestly, nutrition is the most complicated story.
我想先对大家说的一点是,没有一种饮食方案适合所有人。
And I think the first thing that I wanna just say for everyone is that there's not a one size fits all nutrition strategy for all humans.
为什么会这样呢?
And why is that?
因为不同的人有不同的敏感性、过敏反应、偏好,肠道菌群也不同,还继承了父母不同的基因和表观遗传特征。
Because different humans have different sensitivities, allergies, preferences, they have different gut microbiota, they have different genetics and epigenetics that they inherited from their parents.
每个人都不一样。
They have all sorts of differences.
所以有些人吃某种饮食会特别好。
And so some people are going to do really well on one type of diet.
有些人吃全谷物特别棒,但另一些人则对麸质极度敏感,比如患有乳糜泻。
Some people might do really great with whole grain foods, and others might have gluten insensitivity in the extreme form of celiac disease.
对这样的人来说,吃全谷物反而会很糟糕。
And that person is going to do horribly with whole grain foods.
所以根本不存在一刀切的方案。
And so there's no one size fits all.
有些人吃坚果状态特别好。
Other people might do great with nuts.
但也有人对坚果有致命过敏。
Other people might have fatal allergies to nuts.
我们得承认,人与人真的不一样。
We just have to acknowledge people are different.
这正是我在听播客或接受采访时经常遇到的难题——人们总希望我给出三条适合每个人的建议。
And that's one of the things that I I'm always challenged by in even, like, podcasts or interviews is people are like, well, give me the three recommendations for everyone.
但实际上,这做不到。
And it's like, well, it's not
确实不可能。
It's not possible.
对。
Yeah.
可惜的是。
Unfortunately.
所以我想说,事情没那么简单,但又不想让人听到这句话就误解。
So I wanna say it's not that simple, but I don't want people to hear that phrase.
别把‘没那么简单’听成‘根本不可能’。
It's not that simple and hear it as it's impossible.
所以就以为这事根本行不通。
Therefore, it's impossible.
这并不是做不到的。
It's not impossible.
这也不是什么高深的技术。
It's not rocket science.
你只需要懂一点,再愿意稍微尝试一下就行。
You just have to know a little bit, and you just have to be willing to experiment a little bit.
我通常推荐的一个普适原则,结合我们之前讨论过的超加工食品,就是吃真正天然的完整食物——那种你祖父母辈可能在餐桌上见过的食物。
I think the universal principle that I usually recommend, very appropriate based on all of the stuff that we've already discussed about ultra processed foods is eat real whole foods that your great grandparents may have seen on their table, on a plate, somewhere, somehow.
你可以自己动手加工它们。
And you can process them yourselves.
可以做成炖菜、菜肴,随便你怎么弄。
You can make them into stews or dishes or whatever.
如果你喜欢土豆泥,把土豆压碎也没问题。
I mean, you can mash the potatoes if you're into mashed potatoes.
你完全可以对食物做各种各样的处理。
You can you can do all sorts of things with your food.
我完全不反对用香料和其他天然食材让食物更美味。
And I'm not at all opposed to making your food delicious with adding spices and other things to it.
但这些都属于真正的天然食材,不像你在超市塑料袋里买来的那些东西,成分复杂得连名字都念不出来。
But those are all real whole foods as opposed to the things that you buy in a plastic bag from the grocery store that have several ingredients that you have no idea how to pronounce.
每个人的食物选择和饮食结构都会不一样,因为我们每个人都不一样。
The foods and the actual makeup of our diet will look different for everyone because we're so different.
那我们该怎么看待炎症这样的指标呢?
But what do we need to know then about markers like inflammation?
我觉得这些才是更普遍、更关键的问题,对吧?
I think those are the things that are more common, right?
你还提到了线粒体。
You mentioned there mitochondria as well.
这些其实都是我们身体里很重要的部分,值得我们更深入地去了解。
It's like, these are the things that are parts of us that we need to understand more deeply.
只有真正理解了这些,我们才能弄清楚哪些食物适合我们,哪些不适合。
And then that will help us figure out, well, what foods are right for us and those that are not.
这么说对吗?
Is that accurate?
我觉得没错。
I think it is accurate.
我对饮食和营养的看法其实非常复杂。
And I think about diet and nutrition in actually really complex ways.
大多数人只想着吃够有营养的东西来保持健康。
Most people think about it as making sure you get enough nutritious stuff to promote health.
所以最常听到的说法就是‘营养密集型食物’。
So the most commonly used term is nutrient dense foods.
多吃营养密集型食物,就没问题了。
Eat nutrient dense foods and you'll be good.
那超加工食品有什么问题呢?
And what's wrong with ultra processed foods?
其实也不是说它们有什么坏处,只是营养太单薄了。
Well, nothing really is wrong with them, but they are nutrient deficient.
你只是在摄入热量,却缺少身体所需的那些营养成分。
You're just eating calories without the good nutrients that you need.
而且
And
有些营养师甚至会这么说。
so some dietitians will even say that.
你尽管吃你爱的超加工食品,但别忘了时不时加点西兰花。
Go ahead and eat all the all the ultra processed foods you want, but then throw in some broccoli here and there.
可惜,这种方法行不通。
Unfortunately, that's not gonna work.
所以,营养确实是必需的。
So there is a need for nutrition.
人体需要营养,需要各种维生素、足够的蛋白质,以及其他各种必需成分。
There is a need for nutrients, for all the different vitamins and adequate amount of protein and other things that we need.
对。
Yes.
确实如此。
That's true.
但饮食和饮食干预的意义远不止于此。
But diet and dietary interventions can be so much more than that.
有些人需要减重,这时候我们就得制定策略,帮助他们实现目标。
Some people may benefit from losing weight in which we want to come up with strategies to help them accomplish that.
还有些人其实代谢出了问题,因为他们营养不良或者体重过轻。
Other people can actually be metabolically compromised because they are malnourished or underweight.
想想神经性厌食症患者,或者癌症患者,他们长期严重抑郁,吃不下东西,总是恶心,食欲全无,实际上已经快饿死了。
So think of somebody with anorexia nervosa, or a cancer patient with severe unrelenting depression who can't eat or just has completely lost his appetite and is nauseous all the time and is now starving to death really for all intents and purposes.
我觉得他们同样面临代谢问题,但根源是营养不良。
I would actually argue that they too have a metabolic problem, but it's malnutrition.
就是缺乏身体必需的营养素。
It's a lack of essential nutrients.
所以对这些人来说,干预方法很简单:多吃点。
And so the intervention for those people is eat more.
我们需要帮你补充储备。
We need to replenish your stores.
如果可能的话,我们需要让你摄入的热量超过消耗。
We need to get you to have a calorie surplus if possible.
你看,我刚刚提到的这两种方法完全是相反的。
So right there I just mentioned two polar opposite interventions.
一组人需要减重,另一组人则需要增重。
One group needs to lose weight, another group needs to gain weight.
还有一类人对某些食物敏感,他们可能会做排除饮食,或者试着找出哪些食物会引起不适,哪些对自己有益,哪些反而有害。
And then there are people who have food sensitivities, so they might do elimination diets, or just try to figure out what am I sensitive to, what do I thrive on, what don't I thrive on.
最后一种我常提到的饮食干预,本身就可以成为一种治疗方法。
And then the final category that I usually talk about is kind of a dietary intervention that can actually become a treatment unto itself.
通常是通过禁食或者模拟禁食的饮食方式来实现。
It's usually in the form of fasting or a fasting mimicking diet.
模拟禁食的饮食方法有很多种。
And there are many types of fasting mimicking diets.
最广为人知的可能是生酮饮食,但还有其他几种。
Probably the most commonly known one is a ketogenic diet, but there are others.
还有一种植物性、低热量的模拟禁食饮食,研究者沃尔特·隆戈在这方面挺有名的。
There are plant sourced, low calorie fasting mimicking diets that researcher Walter Longo is kind of known for.
但归根结底,这些方法的核心都是让你暂时不吃东西,或者让身体误以为你在禁食——其实你并没有真饿着,生酮饮食的巧妙之处就在于此,它让身体以为自己在禁食,实际上你还在吃东西。
But ultimately, they are all centered on this process of going without or tricking your body that maybe it is going without even when it's not, which is kind of the sneaky thing about the ketogenic diet is it tricks your body into thinking that it's fasting when it's really not fasting.
不过要提醒一点,人不能一直禁食,那叫挨饿,坚持一周左右就会有生命危险。
But the reason that is important to just note is that, you know, people should not fast forever for good health because that's called starvation, and you'll die within a week or so.
对健康一点好处都没有。
Not good for your health.
所以这并不是一种每个人都该长期坚持的健康饮食方式。
And so this isn't technically a lifelong healthy diet that everybody should be on.
但在合适的时间、合适的条件下,它确实能发挥强大的修复作用。
And yet it can have powerful healing properties when done for the right amount of time in the right circumstances.
有些人可能会对这个持怀疑态度。
I mean, some people might be skeptical of this.
所以,如果有人还不清楚,我想指出的是,地球上每一个文化几千年来都把禁食当作一种疗愈方式或宗教实践。
So in case anyone is, I just wanna point out every culture on earth has used fasting as either a healing practice or a religious practice for millennia.
对。
Mhmm.
我觉得这绝非偶然。
I don't think that's a coincidence.
我认为,世界各地的人们都发现,一旦禁食,有时候真的会发生奇迹。
I think that humans in every culture on earth have noticed, gosh, when we fast, miracles can sometimes happen.
是的。
Yeah.
不同的文化或宗教会把禁食的作用归因于神明的慈悲与治愈,诸如此类。
And different cultures or religions have attributed the mechanism of action to God, you know, showing mercy and healing or whatever.
还有其他各种说法,比如我们是在驱赶那些明显存在的邪灵。
A variety of other, you know, we're we're exercising the demons that were clearly present.
对。
Mhmm.
几千年来,人们提出了各种各样的解释。
And so all sorts of explanations have been evoked over millennia.
作为医生和科学家,我想说的是,科学现在终于跟上了,简直让人惊叹。
And what I'm here to say as a physician and scientist is that the science is now catching up to say, woah.
禁食确实对身体和大脑产生了许多惊人的效果,它能促进康复。
This actually is really doing a lot of amazing things in the body and brain, and it is promoting healing.
如果有人信仰特别虔诚,对我这样讲觉得不太舒服,那也没关系——上帝很可能也是通过生物学和生理学在起作用。如果你愿意说这是上帝的旨意,是上帝希望我们做的,是祂在我们禁食时展现慈悲,那祂依然可能是通过科学机制来改变身体、让这一切生效的。
Now if anybody's super religious and they're a little annoyed with me for saying it like that, God was probably involved in biology and physiology So if you wanna stick with this is God's thing, this is what God wants us to do, and he shows mercy, when we do it, well, he would still probably work through scientific methods to change biology and make it work that way.
我不确定。
I don't know.
但关键在于,我们可以更精细地运用这些方法,针对合适的人、在合适的时机,来促进康复。
But that's the thing where we can start to get really sophisticated with using these interventions with the right people in the right circumstances to promote healing and recovery.
你之前提到过,你的某些患者有精神分裂症或双相情感障碍,你说他们不会满足于这些表面的解决方式。
Earlier you mentioned clients of yours or people who are struggling with schizophrenia or bipolar, and you're saying that they wouldn't appreciate these more surface level solutions.
我们先说双相情感障碍吧,我觉得这个话题我们听得更多一些。
We'll start with bipolar, which we hear about a lot more often I feel.
那到底是什么?
What is it?
有多少人正在受这个问题困扰?
How many people are struggling with it?
那通常有哪些推荐的做法?
And what are some of the recommended steps there?
双相情感障碍就是那种发病率急剧上升的疾病之一。
So bipolar disorder is one of those disorders that is skyrocketing in prevalence.
为什么会这样?
Why is that?
我觉得,不管是哪种诊断标签,大家对背后的原因都争议很大。
I think that with all of them, with all of the different diagnostic labels, there's so much disagreement about why is that.
这确实是个关键又重要的问题。
It's such a critical question and an important question.
我想明确说一下,我完全理解不同的解释都存在。
And I just wanna say for the record, I fully understand that there are different explanations.
我觉得这些解释大致可以分成三类。
And the explanations fall into kind of three categories, I would say.
第一类,是我们现在更能识别和诊断出来了。
Category one, we're just better at recognizing it and diagnosing it.
这当然是好事。
And that's a good thing.
这真的非常好。
It's a really good thing.
现在人人都在谈论心理健康。
Everybody's talking about mental health today.
连《有目的》播客都在聊心理健康。
We've got On Purpose Podcast talking about mental health.
所以自然大家都去检查、去接受治疗了。
And so of course everybody is just getting diagnosed and getting the treatment they need.
但要说发病率真的在飙升,尤其是双相情感障碍这种病,很多人觉得它跟基因有关,这不太可能。
But the rates can't possibly really be increasing, especially with something like bipolar because many in the field believe it's genetic.
这种病的发病率不可能在这么短的时间内就发生改变。
And that wouldn't change in prevalence over such a short period of time.
第二类是怀疑态度。
The second category is disbelief.
这怎么可能是真的呢。
This can't possibly be true.
美国人就是爱抱怨、又懒。
Americans are just whiny, lazy people.
现在人人都喜欢给自己贴个标签。
Everybody loves to have a label.
大家都想显得与众不同。
They all wanna be special.
现在人人都想与众不同,都想有个标签,最好还多几个。
Everybody wants to be special these days, and they all want a label or more.
所以大家都想说自己有注意力缺陷多动症。
And so that everybody wants to have ADD.
每个人都有这么或那样的诊断。
Everybody's got one that has has this, that, the other.
这么多人不可能真有这么多精神健康问题,这根本是假的。
And there's no way this many people can really have this many mental health conditions, and so it's all fake.
或者跟这有关,有些人就是喜欢吃药,比如多动症患者。
And or kind of related to that, people are just seeking pills because they like the pills, so with ADHD.
人人都想吃兴奋剂。
Oh, everybody just wants to be on stimulants.
他们都在钻系统的空子。
They're all gaming the system.
一个个跑去精神科,说自己有注意力缺陷的症状,其实根本不是那么回事。
They're all going into the psychiatrist complaining about how they have symptoms of ADHD when they really don't.
他们真正想要的,就是那些药。
And really what they just want is their they want their drugs.
他们想要阿得拉和利他林,而且已经上瘾了。
They want Adderall and Ritalin, and they're hooked on them.
这就是问题的核心。
And that's what that's about.
第三类人呢,是真正有状况的。
And then the third category is no folks.
这一类人的比例其实正在上升,而我就属于这一类。
They're they're really actually going up in prevalence, and I'm in that category.
我不是说另外两类完全不存在。
Not to say that the other You're
一种潮流罢了。
a fad category.
我也没说另外两类完全不会发生。
Not to say that the other two can sometimes occur.
是的,我确实认识一些人,他们喜欢贴标签,甚至过于依赖这些标签来获得关注。
Yes, I do know some people who like labels and probably like them too much and want attention from them.
是的,我也认为现在大家更愿意谈论心理健康了,也确实比三十年前更早发现了一些原本会被忽略的病例。
And yes, I do think that we are talking about mental health more, and we are diagnosing people who maybe would have been missed thirty years ago.
我觉得这确实是真实的。
I do think that's real.
我不是说这些情况不真实,但我觉得大部分数据背后的原因很惊人,因为统计数据实在太吓人了。
So I'm not saying that those aren't true, but I think the bulk of the statistics because the stats are staggering.
仅在美国,双相情感障碍的成人发病率已经翻了一倍,儿童和青少年中的发病率更是呈指数级上升。
With bipolar disorder in The United States alone, the rates have doubled in adults, and they're up exponentially in children and adolescents.
说到儿童和青少年,有一项研究甚至发现诊断率飙升了4000%。
And like with children and adolescents just to I mean one study found a 4000% increase in the diagnosis.
这主要是因为上世纪六七十年代,根本没人会给儿童诊断双相情感障碍。
That was largely because in the 1960s and 70s nobody diagnosed children with bipolar disorder.
现在呢,只要孩子有点坐不住、情绪不稳定、爱发脾气,我们就可能直接贴上双相的标签,可这根本不符合双相的医学定义。
And now we're kind of you know, if they're a little fidgety and moody and throw tantrums, We might label that bipolar even though it's not really the definition of bipolar at all.
有些人一看到这些表现,就会诊断为双相,然后就开始治疗。
Some people will diagnose that as bipolar and start treating it.
双相情感障碍的常规治疗主要是情绪稳定剂,还有大量其他精神类药物。
The usual treatments for bipolar disorder are mood stabilizers and pretty much mood stabilizers and lots of other psychiatric meds.
但不幸的是,太多人对这些药根本没反应。
And the unfortunate reality is far too many people don't respond to those.
确实有人效果特别好,我完全支持这种情况。
There are some who respond beautifully to them, and I'm all for that.
但没效果的人实在太多了。
Far too many don't.
既然效果不佳,为什么还在大量开药?
Why are they still being given out if they don't work?
我觉得是因为一个半真半假的说法——它们偶尔对某些人确实有用。
I think it's it's because of that half truth that they do sometimes work for some people.
于是就有人在街头巷尾,至少在舆论上大声疾呼:这药救了我的命。
And so you'll have people marching in the streets kind of figuratively at least saying this saved my life.
别把这药拿走。
Don't take this away.
但任何了解双相障碍患者的人都知道,绝大多数人根本无法通过治疗达到缓解和康复。
But for anybody who knows anyone with bipolar disorder, the overwhelming majority of people do not achieve remission and recovery from the treatment.
我们这个行业告诉他们,你只是得了慢性病。
And we as a field tell them you just have a chronic disorder.
这种病会伴随你一生。
You'll have this for life.
我们真的非常抱歉。
We're really sorry.
精神科里没有治愈一说。
We don't have cures in psychiatry.
根本就不存在什么根治。
There's no such thing as a cure.
你只能尽力而为,学会与它共处。
And you're just going to have to do your best and manage.
我们会尽全力帮助你。
We'll our best to help you.
但说实话,你可能还是会时不时住院,而这根本不是你的错。
But, yeah, you'll probably be in and out of hospitals sometimes through no fault of your own.
你按时吃药,一丝不苟,可一到换季,症状还是会出现。
You'll be taking your pills religiously, and then the season will change, and you'll have an episode.
我们真的就是
And we just we just don't
不知道该怎么应对这种情况。
know what to do about that.
我觉得
I think
你真正想问我的,大概是饮食对这些人能起到什么作用吧。
what the real question you were probably asking me was how could diet play a role for them?
对。
Mhmm.
当人们听我说饮食可能对严重精神疾病有帮助时,大多数人还是持怀疑态度。
You know, when people hear me talk about diet can play a role for severe mental illness, most are still skeptical.
但我们现在已经有成百上千,甚至可能上万的双相障碍患者,通过生酮饮食或模拟禁食的饮食方式,显著改善了症状,甚至达到了缓解。
But we now have absolutely hundreds, but probably I've heard from thousands of people who've been diagnosed with bipolar disorder, who have experienced significant improvement and or remission of their symptoms using ketogenic diets or fasting mimicking diets.
我想先说明一下,因为对有些人来说,‘生酮’这个词本身可能会让人不舒服。
And I wanna just say upfront, because some people ketogenic can even be kind of a triggering word for some people.
我特别想强调,你可以选择纯素生酮饮食。
And I just wanna say upfront, you can do a vegan ketogenic diet.
你也可以选择素食生酮饮食。
You can do a vegetarian ketogenic diet.
当然,也可以选择杂食生酮饮食。
You can do an omnivore ketogenic diet.
甚至全肉生酮饮食也是可行的。
You can do a carnivore ketogenic diet.
所以,生酮饮食涵盖的食物范围其实很广。
So there's a broad range of foods that people can eat and be on a ketogenic diet.
关键不在于食物是植物性还是动物性来源。
So it's not about plant sourced versus animal sourced foods.
也不是说非得天天吃培根。
It's not about eating bacon all the time.
有些人确实这么吃,对他们来说也算生酮,但如果你不想顿顿吃培根,也没必要非得这样。
Some people make it that, and that it can be ketogenic for them, but it doesn't have to be all bacon if you don't want it to be all bacon.
说实话,光吃培根肯定不是什么健康饮食。
And all bacon probably is not a healthy diet, I'll just say for the record.
你肯定需要比这更全面的营养。
You probably need a little more nutrition than that.
面对那些持怀疑态度的人,我第一句通常会说:这怎么可能呢?
Usually the first thing that I say for the skeptics who are like that, there's no way that can be true.
听起来太离谱了,简直疯了,好像他在胡说八道。
This sounds unbelievable or crazy or it sounds like he's a quacker.
他肯定在卖东西。
He's selling something.
很多人都这么想。
A lot of people think that.
你就是在推销什么吧。
You're selling something.
其实,我从没因为有人采用生酮饮食而拿过任何版税。
I'm like, well, actually, I don't get paid any royalties for people who do ketogenic diets.
要是能拿就好了。
I wish I did.
真希望有个生酮协会,每有一个人尝试,就给我发一毛钱版税,可惜没这回事。
I wish there was a ketogenic society that would give me a 10¢ royalty or something for everybody who tries it, but no such luck.
我想跟所有怀疑的人说清楚一点:很多人觉得生酮饮食只是个流行的减肥法,但其实它早在一百年前就由一位医生发明了,目的只有一个——控制癫痫发作。
I think one of the really important things to just point out for any skeptics right off the bat is that although a lot of people know that keto diet is this fad weight loss diet, in fact it was developed a hundred years ago by a physician for one and only one purpose, and that is to stop seizures.
生酮饮食本质上是一种治疗癫痫的方法。
That the ketogenic diet is an epilepsy treatment.
真的吗。
Wow.
而且现在它已经被证实是经过科学验证的癫痫疗法。
And it is actually now an evidence based epilepsy treatment.
我们有大量对照试验的支持。
We have many controlled trials.
我们有两项被医学界视为金标准的系统评价——考科蓝综述,证实生酮饮食对癫痫,尤其是儿童癫痫,具有非常显著的疗效,即使药物无法控制发作时也有效。
We have two kind of gold standard medical reviews called the Cochrane Reviews that support that the ketogenic diet is a very effective treatment for epilepsy, especially childhood epilepsy, even when medications fail to stop the seizures.
这一点特别重要,因为事实上,我们经常把治疗癫痫的药物用于多种精神健康问题,尤其是双相情感障碍。
And the reason that's so important to point out is that it turns out that we use epilepsy treatments for a wide range of mental health conditions, but in particular bipolar disorder.
很多抗癫痫药,比如德巴金、卡马西平、拉莫三嗪、加巴喷丁等等,最初都是为治疗癫痫而研发的。
So a lot of anticonvulsants like dabicote, Tegretol, Lamictal, Gabapentin, others are used for they were actually developed initially for epilepsy.
这些药本质上是抗癫痫药,但大多数听众如果听过这些名字,多半是因为它们常被当作精神科药物开给患者。
They're really epilepsy pills, but most of your listeners, if they recognize any of those names, they recognize them as psychiatric pills or psychiatric medications because they're most commonly prescribed for that.
所以,既然我们早就把治疗癫痫的药物广泛用于精神健康领域,那就不该惊讶,一种能控制癫痫发作的饮食,也可能对某些人有帮助。
And so in a way, given that we use epilepsy treatments all the time for mental health conditions, it shouldn't be shocking that a diet that can stop seizures might also play a role for some people.
是的。
Yeah.
真没想到。
Wow.
我以前完全不知道。
I had no idea.
这太令人着迷了。
That's fascinating.
我是说,我们是怎么发现,一百年前用过的疗法,现在居然又能派上用场的?
Like, how did we even discover that something that was used a hundred years ago for that was possible now to use again?
第一项关于精神健康的研究发表于1965年。
The first published study for mental health was in 1965.
一些研究人员对患有精神分裂症的女性进行了研究,让她们只坚持了两周的生酮饮食,结果发现她们的症状至少有所改善。
Some researchers did a study of women with schizophrenia, put them on a ketogenic diet for just two weeks, and they noticed at least some improvement in their symptoms.
大多数人甚至根本没认真考虑过,也没去想过这一点。
Largely, people haven't even really seriously considered it, or thought about it.
通常人们都默认,精神疾病患者没法坚持饮食控制。
And the usually, the assumption is that people with mental illness can't do a diet.
没错。
Right.
这话说得对。
That's I mean yeah.
人们觉得精神疾病患者太虚弱了。
People with mental illness are too impaired.
他们病得太重了。
They're really sick.
根本不可能让他们节食。
There's no way they could do a diet.
但是呢?
But?
我想说的是,请别低估他们想要康复的决心。
What I'm here to say is that please don't shortchange them and underestimate their determination to get better.
我现在正在帮助患有精神分裂症、双相情感障碍和严重抑郁症的人改变饮食,并坚持下去。
Because I'm getting people with schizophrenia and bipolar disorder and crippling depression to be able to change their diet and stick with it.
当人们为生命而战时,即使身体状况很差,他们也能展现出惊人的能力。
When people are fighting for their life, it's really amazing what they're capable of doing even when they're so impaired.
即使他们的状况已经很差了。
Even when they're so impaired.
我不是来说他们没有障碍的。
I'm not here to say they're not impaired.
我也不是来说这很容易的。
I'm also not here to say it's easy.
我不是想说,随便告诉他们一个生酮饮食,两天后就能痊愈了。
I'm not here to say like, oh, just tell them ketogenic diet and then two days later they're gonna be cured.
事情不是这么做的。
That's not the way this works.
他们需要支持,需要教育,需要大量的帮助。
People need support, they need education, they need a lot of help.
他们真的需要大量的帮助。
They absolutely need a lot of help.
但这完全是可能的。
But it is possible.
这是可以做到的。
It is doable.
当我们支持这些人时,他们是能做到的。
And when we support these people, they can do it.
好消息是,虽然有些人可能觉得这听起来像是个案,或者以为Chris Palmer在编故事,但目前全球已经有20项关于生酮饮食治疗多种精神健康问题的对照试验正在进行。
And the, you know, the great news is that although to some people this may sound anecdotal or Chris Palmer's making stuff up or what, We now have 20 controlled trials underway around the world of the ketogenic diet for a wide range of mental health conditions.
其中八项是随机对照试验。
Eight of them are randomized controlled trials.
我们还有几个初步试验,以及大量已发表的病例报告。
And we have several pilot trials, many case reports already published.
我刚刚发表了一篇综述文章,梳理了生酮饮食在精神健康领域被应用的频率。
I actually just published a review article on this topic of how often has the ketogenic diet been used for mental health conditions.
目前文献中已发表的相关研究超过50篇,参与这些试验的人数超过1900人。
We have over 50 publications already published in the literature, and over 1,900 people, 1,900 people who participated in these trials.
其中绝大多数人都报告了某种程度的改善。
And the overwhelming majority of them found some benefit.
但我并不是想说所有人都完全康复了,因为精神健康问题远比单纯饮食要复杂得多。
Now I'm not trying to say all of them were cured of their mental health condition because mental health is a lot more complicated than just diet.
我并不是说某一种治疗方法能神奇地治好所有人,因为事情没那么简单。
And I'm not here to say any one treatment is gonna magically fix everyone, because that's not the way it works.
我收到来自世界各地许多饱受慢性、严重且致残性精神疾病困扰的人的反馈,其中很多人实现了完全缓解,有时甚至停用了精神类药物。
And I hear from people around the world who have suffered from chronic severe crippling mental illnesses, and a lot of them are getting full remission, sometimes off of their psychiatric medication.
他们有时能够完全逐渐停药。
Sometimes they're able to completely taper off.
而且即便是这样,当他们获得缓解时,这个过程也并非像想象中那么简单,这确实让人感到惊讶。
And even that, like when they get remission, it's not like this simple process, shocking, surprisingly.
因为大家可能会觉得,哎,如果病情缓解了,他们应该高兴得又蹦又跳,一直笑才对。
Because you would think that like, oh, if I put them into remission, they should be so happy jumping up and down for joy, smiling all the time.
确实有一部分人是这样。
And there's some of that.
但几乎每个人都会经历一个阶段,就是为自己失去的人生感到深深的悲痛。
There's also this phase that almost everybody goes through of profound grief for the life that they've lost.
他们会意识到,自己刚刚把三十年的生命都耗费在了这场疾病上。
They recognize I just lost thirty years of my life to that illness.
天啊。
Wow.
为什么三十年前没人告诉我这些呢?
Why didn't somebody give this to me thirty years ago?
因为那时候我还在上大学。
Because I was in college.
我有个女朋友。
I had a girlfriend.
我们本来打算结婚的。
We were gonna get married.
可当我患上精神分裂症后,我失去了一切。
And when I became schizophrenic, I lost everything.
我不得不退学。
I had to drop out of college.
从那以后,我再也没谈过恋爱。
I've never had a girlfriend since.
我失去了所有朋友。
I lost all my friends.
我再也无法独立生活了。
I couldn't live independently anymore.
我胖了很多。
I gained all this weight.
这三十年来,我一直被社会排斥。
I've been a pariah in society for thirty years.
现在我好起来了?
And now I'm better?
那我接下来该做什么?
What am I supposed to do?
克里斯,听你这么说,我觉得我们已经谈了宏观,也谈了微观,但当你这样描述时,我忍不住想,是什么让你把一生都献给了这份工作?
Chris, when I'm listening to you, I'm thinking we've talked about the macro, we've talked about the micro, but when I'm hearing you talk about it that way, I'm like, what made you dedicate your life to this work?
这不只是你做的事,这就是你本身。
Because this isn't just something that you do, it's who you are.
从你对这份工作的热情,还有你每天对待支持和服务对象时投入的能量,就能看出来。
You can tell by the passion you have for it, the energy you have for the people that you support and serve and work with every day.
就像你自己说的,从商业角度看,你其实并没有直接的利害关系。
Like you said, you don't have any skin in the game when you look at it from a business point of view.
那这份动力到底从何而来?
So where's that coming from?
我从小就很早就开始经历精神健康方面的困扰,
I have had my own struggles with mental illness from a very young age in terms
了
of
比如强迫症,后来发展成严重的抑郁,甚至有过自杀的念头,各种问题都经历过。
OCD, later crippling depression, suicidality, all sorts of things.
如果你愿意,我很乐意以后详细聊聊这些经历。
And I'm happy to go into that at some point if you want to.
但我最终选择成为精神科医生,真正的原因是因为我妈妈。
But the real reason I ended up becoming a psychiatrist is because of my mother.
我家里一共有八个孩子。
I'm from a family of eight kids.
我妈妈四十岁出头的时候,之前一直还算正常。
And when my mom was in her early 40s, she had been relatively, quote, unquote, normal up until then.
就是专心带孩子,帮爸爸打理生意,过着中西部典型的中产生活。
Just raising a family, helping my father run his business, just living a normal middle class life in the Midwest.
她家里接连发生了一连串让人难以承受的变故,压得她喘不过气。
A series of events happened in her family that were ridiculously stressful and put a tremendous burden on her.
她先是出现了一种她说的‘精神崩溃’,很快演变成重度抑郁和自杀念头,紧接着又出现了幻觉等精神病性症状。
And she had what started as what she called a nervous breakdown that quickly turned into depression and suicidality, and then pretty quickly turned into psychotic symptoms.
她被送进了医院。
And she was hospitalized.
开始服药治疗。
She was medicated.
也在接受心理治疗。
She was getting psychotherapy.
她接受了精神健康领域能提供的一切治疗。
She was getting all of the treatment that the mental health field had to offer.
但全都无效。
None of it worked.
她余生都饱受慢性精神病的折磨,人生彻底被毁了。
And she ended up living the rest of her life with a chronic psychotic disorder, and it ruined her life.
这绝不是轻描淡写。
It's not an understatement.
她失去了对所有
She lost custody of all of
八个孩子的监护权。
her eight kids.
我曾经去和她一起住过一段时间。
I went to live with her for a while.
后来我们一度无家可归。
We end up homeless together for a while.
我的意思是,那简直是一场噩梦。
I mean, was a nightmare.
但她失去了对孩子们的监护权。
But she loses custody of her kids.
她失去了自己的生意。
She loses her business.
她失去了所有的钱。
She loses all of her money.
她因为这种精神病性障碍,失去了朋友、家人,还有许多其他东西。
She loses friends, family, all sorts of things due to this psychotic disorder.
我亲眼目睹了这一切发生。
And I saw all of that happen.
我对整个精神卫生系统感到无比愤怒。
And I was furious with the mental health field.
极度愤怒。
Furious.
他们怎么这么无能?
Why are they so incompetent?
他们为什么不帮帮她?
Why aren't they helping her?
我当时
Like, I
我知道她有问题。
knew there was something wrong with her.
很明显。
It was clear.
她有妄想。
She was delusional.
她觉得自己是抹大拉的马利亚转世。
She thought she was Mary Magdalene reincarnated.
她觉得世界末日就要来了。
She thought the world was ending.
她会对周围的人产生妄想和猜疑。
She would get paranoid about people.
我的意思是,各种症状都出现了。
I mean, all sorts of symptoms.
所以我早就觉得她不对劲,
So I knew there was something wrong with her,
但我实在无法相信,精神健康领域竟然能这么无能。
but I was just in disbelief that the mental health field could be so incompetent.
他们为什么不去帮她?
Why aren't they helping her?
他们为什么不能让她好起来?
Why aren't they making her better?
他们有医院啊。
They have a hospital.
他们到底在干什么?
What are they doing?
当
And when
我看到他们对她做的事,简直吓坏了——给她吃那些药,整个人像行尸走肉,可精神状态还是乱七八糟。
I saw what they were doing, I was horrified because they were putting her on medicines that made her seem like a zombie, but she was still crazy.
我当时就想,他们到底在干什么?是故意在害她吗?
And I was like, what what are they do are they poisoning her on purpose?
这到底算什么?
Like, what what is that?
他们到底在搞什么名堂?
Like, what what are they doing?
最后,正是她的经历让我决定成为一名精神科医生,因为我亲眼目睹了精神疾病有多摧残人。
And ultimately, she's the reason I became a psychiatrist because I saw how devastating mental illness can be.
不过幸运的是,并不是每个人都会这么惨。
It's not that devastating for everybody, thankfully.
有些人症状比较轻或者中等,那就好了。
Some people have mild, moderate things, and that's great.
但我看到,精神疾病真的能毁掉一个人的一生。
But I saw that it can literally ruin a person's life.
它能摧毁整个家庭,而她完全是无辜的。
It can ruin an entire family and that she was innocent.
她什么都没做错,不该承受这些。
She didn't do anything to deserve any of that.
她没有吸毒。
She wasn't using drugs.
她根本没做错任何事,一点责任都没有。
She wasn't there was no blame.
她完全不该为这一切负责。
No way to blame her for any of it.
于是我选择了这个行业,希望至少能做点不一样的事,带来一些改变。
And I went into the field hoping that maybe somehow I might be able to make a difference and do something different.
谢谢你分享这些。
Thank you for sharing that.
你能把痛苦转化为动力,真的让人佩服。虽然我没法想象这些年你看着这一切却无能为力,心里有多难受,肯定也感到绝望过。
It's incredible that you were able to, you know, turn a pain into a purpose for you, even though I can't imagine how painful it was over those years just watching that and feeling helpless I'm sure at times and hopeless.
你觉得如果现在知道了这些,是不是会有不同的方法来帮助和支持她?
Do you believe that if you knew what you know now then that there were different ways of helping and supporting her?
绝对是。
A 100%.
你知道,当我……
You know, when when I
后来我进了精神科,结果成了那种只会开一堆没多大用处的药的‘坏医生’。
went into psychiatry, I became one of those evil psychiatrists who just doled out pills that didn't really work.
那时候我觉得特别无力,也对这个行业感到特别绝望。
And I felt so helpless and so hopeless for our field.
是因为你不得不这么做吗?
Because you had to?
还是说
Or
因为那是我唯一能用的手段,人们往往会陷入危及生命的状况。
Because those were the only tools that I had available, and people would end up in life threatening situations.
他们会出现躁狂和精神病症状,对自己或他人构成威胁,我们总得做点什么。
They would be manic and psychotic and a danger to themselves or others, and we had to do something.
我们必须让他们活下来,或者我总觉得有责任让他们活下来,而这是我唯一学到的办法。
We had to keep them alive, or I felt compelled to try to keep them alive, and that was the only tool that I had learned about.
我一直对这些方法持怀疑态度。
I always was skeptical of all of it.
我在精神健康领域做的一切,我都保持着合理的怀疑,因为我明白,当年他们对我妈妈用的也是这套,根本没用。
I always kept a healthy dose of skepticism about everything I was doing in the mental health field because I recognized this is the same thing that they did for my mom and it didn't work.
那为什么我们就该相信这套能管用呢?
So why should we think this is gonna be any better?
但我感到无能为力。
But I felt helpless.
我不知道还能做什么。
I didn't know what else to do.
我现在充满希望,因为当我们把所有这些科学成果整合起来,真正理解一些现在就能实施的干预方法——比如生酮饮食,虽然它对精神分裂症患者大脑的作用机制非常复杂,
I am now filled with tremendous hope that when we put it all together, when we put all of this science together, and we understand some actual interventions that can really be done right now in 2024, like a ketogenic diet, the science of how that would help the brain of someone with schizophrenia gets really complicated fast.
但我能理解这些科学原理。
I can understand that science.
我不行,是的。
I can't, yeah.
其他人不需要懂。
Other people don't need to.
他们只需要知道,我们会让你开始这种饮食,帮您落实,提供指导和支持,弄清楚哪些你能做,哪些你不想做。
They just need to understand that you're going to do this diet, and we're going to help you do it, and we're going to coach you and provide support and, you know, and figure out what what you can do and what you don't wanna do.
这是一种切实可行的治疗方法。
And it's an achievable treatment.
它在2024年的今天就是一种现实、可及的疗法,能够挽救生命。
It's a realistic, accessible treatment today in 2024, and it can save lives.
我最充满希望的是,这种更广泛的理论能帮助我们开发出更多工具、疗法和策略。
What I am most hopeful about is the way that this broader theory can help us develop even more tools and treatments and strategies.
我非常期待,这能迫使我们重新思考领域内许多现行的做法。
And I'm really hopeful it will force us to rethink a lot of what we're doing in our field.
它会促使我们寻找根本原因,并采用更有效的疗法。
It will force us to look for root causes, to use treatments.
有些疗法我认为应该谨慎使用。
Some of them need to be used sparingly, I would argue.
也许只在危及生命的情况下使用,但之后我们必须转向促进健康的治疗方式。
Maybe in life threatening situations, but then we need to move on to health promoting treatments.
我已经五十多岁了。
I'm in my fifties.
我不知道自己还能活多久,但我相信,以我余生的时间,我们完全有可能见证精神健康领域的彻底变革。
I don't know how much more time I have, but I think I have enough time that in my lifetime, I believe it is possible that we will see a transformation of the mental health field.
到那时,我们会回望2024年对精神疾病的治疗方式,觉得它近乎野蛮。
And we will look back on the way we treated mental illness in 2024 as almost barbaric.
对。
Yes.
他们当时是怎么想的呢?
And how could they have done that?
为什么就不采用那些更有效的办法呢?
Like, why why didn't they use these other strategies that are so much more effective?
我非常期待,未来十年到二十年内我们能看到这样的转变。
I am really hopeful that we may see that day in the next ten to twenty years.
如果有家长,或者将来要当父母的人正在听,而且家族中有心理健康问题的历史,他们不想把这些传给孩子,那该注意些什么?
And if there are parents and future parents listening who have in their family had a history of mental health and they don't wanna pass it on to their children, what are the things they should be looking at?
真的有可能不传给下一代吗?
Is it possible to not pass it on?
如果你身上有增加风险的基因,那确实已经传给孩子了。
If you do have genes that increase risk, you have passed them on.
这并不是作为父母的错。
It's not your fault as a parent.
你的父母传给了你,他们的父母也传给了他们。
Your parents did it to you and their parents did it to them.
所以别再为此自责了,别花时间去纠结这个。
And so don't don't spend any time or thought beating yourself up over that.
基因确实会遗传,但短期内我们没法改变这些。
So genetics do get passed on, and we're not changing those anytime soon.
表观遗传也会遗传,可惜的是,这事儿更复杂了。
Epigenetics also get passed on unfortunately, and that gets more complicated.
如果你当父母前经历过创伤,比如童年时被父母家暴,令人意外的是,你已经把那段经历的某些影响传递给了孩子。
It means that if you've been traumatized as a parent, if you had a horrible childhood, your parents physically beat you, surprisingly you have passed at least a glimpse of that experience onto your children.
当人经历创伤,尤其是长期创伤时,会引发一些变化,我们可以简单称之为表观遗传改变。
When people have trauma, especially prolonged trauma, it causes changes in what I think we can safely just call epigenetics.
这可能意味着你的DNA发生了修饰。
And that might mean modifications to your DNA.
也可能涉及微小RNA分子之类的物质,它们能通过卵子和精子传给下一代,影响孩子未来的心理健康和代谢健康。
It might mean like microRNA molecules and other kind of things that actually can get transferred in eggs and sperm cells to new children and can impact their future mental health and metabolic health.
有些部分是无法改变的。
Some parts are unchangeable.
但好消息是,基因甚至表观遗传都不是这些疾病的主要决定因素。
But the good news, the great news, is that genes and even epigenetics are not the primary determinants of these illnesses.
我相信,真正起决定作用的是环境,是我们生活方式。
I believe environment, the way we live our lives is.
最有力的证据就是这些疾病的发病率呈指数级上升。
And the strongest testament to that is actually the exponential rise in rates.
我们的基因并没有改变。
Our genes have not changed.
我们的表观遗传可能发生了变化,但表观遗传本身是可以正向或负向改变的。
Our epigenetics may have changed, but epigenetics can change one way or another.
如果你是孩子的父母,我们会做所有那些常规且显而易见的事。
If you are a parent to a child, we're gonna do all of the usual obvious things.
你会爱自己的孩子。
You're gonna love your child.
你会给孩子提供安全感。
You're gonna provide safety.
你也不会事事替他们包办。
You're not gonna coddle completely.
你要让他们独立,去承担一些风险。
You're gonna let them be independent, take some risks.
要允许他们偶尔失败。
You're gonna let them fail every now and then.
这些你都可以做到。
You're can do all of those things.
你要大力支持并鼓励他们交朋友、融入社群。
You're gonna really support and encourage them to have friends and community.
要让他们多活动,多到户外去,诸如此类的事情。
You're gonna have them move, you're gonna have them get outside, all of that stuff.
大多数父母最大的盲点,就是日复一日允许孩子吃进嘴里的东西。
Probably the single biggest blind spot for most parents is what you're allowing your child to put into his or her mouth day after day after day.
如果他们生活在美國,很大可能吃了很多超加工食品。
If they live in America, there is a very very good chance they are eating a lot of ultra processed foods.
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