第104期：比BPC-157更好？我们来聊聊KPV！KPV的主要益处：肠道健康、抗炎、皮肤与伤口愈合、免疫功能支持，以及与BPC-157的协同作用等！

本期节目由Apollo Neuro赞助。

Today's episode is sponsored by Apollo Neuro.

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Apollo Neuro is the leading doctor recommended wearable technology.

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Not only that, but the Apollo Neuro is the first and only wearable that improves your HRV.

Apollo使用起来毫不费力。

Apollo is effortless.

只需全天候佩戴，让它为您自动完成所有工作。

Simply wear it throughout the day and night and let it do the work for you.

它安全适用于所有人，无任何副作用，是唯一可以佩戴在身体任何部位的可穿戴设备。

It's safe for anyone and everyone with no side effects and is the only wearable that can be worn anywhere on your body.

最佳健康状态需要身心协调，而Apollo正是建立这种连接的关键。

Optimal health requires both the mind and body to be in line and Apollo is the key to establishing that connection.

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Check the description below to save $90 with my special discount.

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Take control over your health today with Apollo Neuro.

现在听好了。

Now listen to this.

它实际上能下调氧化应激通路。

It actually down regulates oxidative stress pathways.

我认为它更强大。

I believe it is stronger.

它能做更多事情。

It does more.

这就像下一代BPC，每个人都会想使用它。

This is like the next generation BPC that everybody's gonna be wanting to use it.

我永远不会对此有任何怀疑。

I will never ever put doubt on that.

比BPC-157更好？

Better than BPC-one hundred fifty seven?

真的吗？

Really?

这可能吗？

Is that possible?

一种会更受欢迎、更广泛使用的物质？

Something that is going to be more popular and more widely used?

哦，我不确定，因为人人都在谈论BPC-157，而这也完全合理，因为它确实非常出色。

Oh, I don't know because everybody under the sun wants to talk about BPC-one hundred fifty seven, and rightfully so because it is tremendous.

但还有其他一些化合物能产生惊人的效果。

But there are other compounds out there that do some amazing things.

我要跟你们聊聊我认为是史上最被低估的多肽。

And I'm gonna talk to you about what I believe is the most underrated peptide in existence.

它是我新最爱的榜首，那就是KPV。

It is at the top of my list of new favorites, and that is KPV.

现在我是戴伦·杰梅利。

Now I am Dylan Gemelli.

在荷尔蒙、肽和生物黑客技术方面，我是你们的专属专家。

I am your resident expert when it comes to hormones, peptides, and biohacking in general.

而且我善于倾听。

And I listen.

我之所以聪明，是因为我常和聪明人在一起，我拥有多年的实践经验、研究和大量现场指导经验，亲眼见证了各种方法的效果，并向全球顶尖人士学习，尤其是在肽领域。

I am only smart because I hang around smart people, and I just have years of experience and study and a lot of on hand coaching, seeing how things work, and I have learned from some of the best people around the world, especially when it comes to peptides.

所以接下来我要谈谈KPV。

So I'm gonna get into some things here talking about KPV.

现在大多数人是通过CLO组合了解到KPV的，因为最初是GLO组合，也就是BPC-157、TB-500和GHK-CU铜肽。

Now most people have kinda learned about KPV through the CLO stack because at first, it was the GLO stack, which we know is BPC-one five seven, TB 500, and GHK CU copper peptide.

但后来我们开始看到CLO组合，我认为它被称为CLO，是因为我们加入了KPV。

But then we started to see the CLO stack, and I believe it was called CLO because we added the KPV to it.

我认为这才是真正的亮点。

I think that is the shining star.

我不会在这里说它比BPC-157更好，但它与BPC-157具有极强的协同作用，因为BPC确实非常出色。

I will not come out here and say that it is better than BPC one five seven, but it is extremely synergistic with it because, look, BPC is phenomenal.

是的。

It is.

身体保护化合物，它是最知名、最值得信赖，甚至可能是现存最权威、最受欢迎的肽之一，这完全实至名归。

Body protective compound, it is one of the most well known, most reputable, if not the most reputable peptide and most popular in existence, and rightfully so.

我永远不会对这一点有任何怀疑。

I will never ever put doubt on that.

然而，KPV与它协同作用的效果非常好。

However, KPV works synergistically with it extremely well.

所以接下来我会向你们解释一下KPV是什么、它有什么作用、我为什么如此喜爱它，然后我们再讨论两者之间的协同效应。

So what I'm gonna do is give you an explanation here on KPV, what it is, what it does, why I love it so much, and then we're gonna talk about the synergy between the two.

它是一种由三种氨基酸组成的三肽。

So it is a tripeptide of three amino acids.

我们说的是赖氨酸、脯氨酸和缬氨酸。

So we're talking about lysine, proline, and valine.

它是一种更大分子的片段，这种分子被称为AMSH，在免疫功能、炎症控制和黑色素生成中起着核心作用。

Now it's a fragment of a larger molecule, and that's known as AMSH, and that plays a central role in immune function, inflammation control, and melanogenesis.

KPV的一个突出且独特之处在于，它保留了AMSH所有的抗炎益处，同时不会刺激黑色素细胞受体。

One of the things that makes KPV a standout and really unique is that it retains all the anti inflammatory benefits of an AMSH without stimulating melanocyte receptors.

因此，它在全身使用时非常安全，不会以任何方式影响色素沉着或激素水平。

So that makes it really safe for systemic use without affecting pigmentation or hormone levels in any way, shape, or form.

现在我来列举一些KPV的好处。

Now I'm gonna run down some of the benefits of KPV.

第一，它具有非常强的抗炎效果。

Number one is that it has really, really strong anti inflammatory effects.

研究表明，它能抑制促炎细胞因子，而这些细胞因子与多种慢性疾病有关。

Now it's been shown to suppress pro inflammatory cytokines, which are implicated in numerous chronic conditions.

这使得它在控制全身性和局部性炎症方面非常有价值，而不会像类固醇那样完全抑制免疫系统。

And this makes it really valuable in controlling systemic and localized inflammation without suppressing the immune system entirely like steroids would.

第二，这也是KPV最广为人知、也是我最喜爱的方面之一：它有助于肠道修复和屏障功能的维持。

Number two, and this is one of the things that I think it's most well known for and one of the things that I absolutely love about it, it supports gut healing as well as barrier function.

KPV应用中最令人兴奋的方面之一是其对肠道黏膜屏障的修复作用。

So one of the most exciting aspects of KPV's application is in healing the intestinal mucosal barrier.

它能促进上皮细胞再生，并减少炎症信号。

Now it enhances epithelial cell regeneration, and it reduces inflammatory signaling.

它促进紧密连接的完整性，这对于解决肠漏综合征和其他食物敏感性、炎症性肠病等至关重要。

It promotes tight junction integrity, and this is crucial for, yes, addressing leaky gut syndrome and other food sensitivities, IBD, etcetera.

第三，我们讨论的是免疫活性的平衡。

Number three, we're talking about a balance of immune activity.

KPV不是抑制免疫，而是调节免疫。

Rather than suppressing immunity, KPV modulates it.

它有助于平息过度活跃的免疫反应，同时不损害防御机制，因此非常适合自身免疫疾病、组胺不耐受、肥大细胞活化综合征（简称MCAS）以及胃肠道疾病。

So it helps calm an overactive immune response without compromising defense mechanisms, which makes it really ideal for autoimmune diseases, histamine intolerance, mast cell activation syndrome, also known as MCAS, gastrointestinal disorders.

它的作用非常多。

So it does a ton.

它还能做什么？

What else does it do?

它能改善皮肤状况。

It improves skin conditions.

它在局部和系统性应用中都能改善银屑病、湿疹、炎症性痤疮，这些效果源于其对炎症介质的抑制以及皮肤屏障功能的恢复。

It has topical and systemic applications in improving psoriasis, eczema, inflammatory acne, and these effects are due to its suppression of inflammatory mediators as well as restoration of skin barrier function.

还有别的吗？

What else?

它能对抗氧化应激。

It protects against oxidative stress.

听好了。

Now listen to this.

它实际上能下调氧化应激通路，减少活性氧物质。

It actually down regulates oxidative stress pathways and reduces reactive oxygen species.

那有什么作用？

And what does that do?

它在细胞层面提供保护，并促进组织修复，尤其是在肠道、大脑和皮肤中。

It gives protection at the cellular level and it improves tissue healing, especially in the gut, the brain, and our skin.

除了我们之前讨论的肠道健康，这是我最喜欢的一个方面。

Here's one of my favorite aspects aside from the gut health that we talked about.

它支持神经健康。

It supports neurological health.

你们最近一定听我多次谈到身心连接了。

You guys have heard me talk a ton now recently about the mind body connection.

你们知道我研究过神经科学。

You know about my studies in neuroscience.

那么它有什么作用呢？

So what does it do?

它能减少神经炎症和氧化应激。

It reduces neuroinflammation and oxidative stress.

我们讨论的是帮助缓解脑雾、偏头痛、与炎症相关的神经退行性问题以及情绪障碍。

So we're talking about helping with brain fog, migraines, neurodegenerative concerns, mood disorders that are tied to inflammation.

现在我们来谈谈它的作用机制。

Now let's talk about mechanism of action here.

它是如何起作用的？

How does it work?

它通过同时靶向多个不同的通路发挥作用。

It works by targeting several different pathways simultaneously.

我接下来要跟你们说一些内容。

I'm gonna throw some stuff out here at you.

它能抑制NF-kB的活化，而NF-kB是一种关键的促炎转录因子。

So it inhibits NFKB activation, and that is a central pro inflammatory transcription factor.

它还能抑制IL-6、TNF-α和MCP-1。

Now it suppresses I l six, TNF a, and m c p one.

这些是常见的炎症细胞因子，同时它还能修复紧密连接蛋白，从而降低肠道通透性。

These are common inflammatory cytokines, and it also restores tight junction proteins, which then reduces gut permeability.

它还能稳定肥大细胞，调节过敏和自身免疫反应，并下调TLR4，减少先天免疫的过度激活。

It also calms mast cells and modulating allergic and autoimmune responses, and it down regulates TLR four, which reduces innate immune over activation.

它的安全性和系统耐受性使其成为抗炎工具箱中一种独特而多用途的肽。

And its safety and systemic tolerance make it a very unique versatile peptide in the anti inflammatory tool kit.

它常被描述为一种抗炎肽，正如你所见，但炎症只是恢复过程中的一个方面。

It's often described as an anti inflammatory peptide, as you can see, but inflammation is only one piece of recovery.

减少炎症有帮助，但愈合才是关键。

Reducing inflammation helps, but healing.

这取决于组织信号、血液循环和修复能力。

This depends on tissue signaling, circulation, and repair capacity.

损伤关节与恢复蓝图解释了KPV这类肽的作用位置，以及为何仅控制炎症是不够的。

The injury joint and recovery blueprint explains where peptides like KPV fit and why controlling inflammation unknown isn't enough.

你必须获取关节与损伤恢复蓝图，认真阅读并了解它。

You gotta get the joint and injury recovery blueprint and read that and learn about it.

那么，谁应该考虑KPV肽疗法呢？

Now who should consider KPV peptide therapy?

它非常适合患有胃肠道问题、炎症、克罗恩病、溃疡性结肠炎、肠易激综合征、肠漏症、食管炎、抗生素后肠道菌群失调、自身免疫和炎症性疾病、银屑病、类风湿性关节炎、桥本甲状腺炎、红斑狼疮、组胺不耐受和MCAS的人群。

It's ideal for people that have gastrointestinal issues, inflammation, Crohn's, ulcerative colitis, IBS, leaky gut, esophagitis, post antibiotic gut dysbiosis, autoimmune and inflammatory conditions, psoriasis, psoriasis, rheumatoid arthritis, Hashimoto's, lupus, histamine intolerance, MCAS.

我的意思是，适用的病症列表很长。

I mean, there's a long list of things.

它有助于稳定肥大细胞，正如我所说，减轻组胺介导的症状并恢复肠道黏膜的完整性。

It helps stabilize mast cells, like I said, reduce histamine mediated symptoms and restore gut lining integrity.

皮肤问题，如我提到的，包括痤疮、湿疹、慢性皮炎，它还能加速组织愈合，并减轻创伤后的炎症，特别是在软组织和黏膜层中。

Skin conditions, like I talked about, acne, eczema, chronic dermatitis, and it also accelerates tissue healing and it dampens post trauma inflammation, particularly in soft tissues and mucosal linings.

BPC-157主要专注于组织修复与再生，而KPV是一种专门的抗炎和免疫调节肽。

BPC-one hundred fifty seven is largely focused on tissue repair and regeneration, while KPV is a specialized anti inflammatory and immune modulating peptide.

因此，它们常被联合使用，以创建一个全面的愈合方案，同时应对身体损伤和炎症。

So they're often used together to create a very comprehensive healing protocol that addresses both physical injury and inflammation.

所以，简单快速地谈一下BPC-157。

So just real quick to touch on BPC-one hundred fifty seven.

BPC-157通过促进血管生成，即新血管的形成来发挥作用。

BPC-one hundred fifty seven works by increasing angiogenesis, which is new blood vessel growth.

它改善受伤部位的血液循环，并加速细胞再生。

It improves circulation to our injured areas and accelerates cell regeneration.

因此，它最适合用于肌腱、韧带、肌肉的损伤，术后恢复，慢性肠道问题如溃疡和关节疼痛，并且以其在消化道等恶劣环境中促进愈合的能力而闻名。

So it's best for injuries like your tendons, ligaments, muscles, postsurgical recovery, chronic gut issues like ulcers and joint pain, and it's known for its ability to promote healing even in harsh environments like the digestive tract.

现在我已经讲完了关于KPV的所有内容。

Now I covered everything there is to know about KPV.

那我们接下来怎么处理这些呢？

What are we gonna do here with these?

我们要把它们叠加使用吗？

Are we gonna stack them?

我们要分开使用它们吗？

Are we gonna use them separately?

你可以单独使用它们，效果完全没问题。

You can use them separately just fine.

我向你保证。

I assure you.

它们各自的效果都非常好。

They do extremely well on their own.

但当它们一起使用时，能形成一种非常协同的疗法，全面改善肠道健康，因为BPC修复结构性损伤，而KPV则减轻导致损伤的炎症。

But when they use together, they offer a very synergistic approach to healing comprehensive gut health because BPC repairs the structural damage while KPV reduces the inflammation that caused the damage.

那么，我们来看看一些高级恢复方法。

Then, let's look at some advanced recovery.

BPC 加速组织修复，而 KPV 管理炎症反应，因此可以缩短整体恢复时间。

So BPC accelerates tissue repair and KPV manages the inflammatory response, so that reduces the overall recovery time.

所以你看，这就像花生酱和果酱，我特别喜欢的一点是，即使单独使用，这些物质也已经非常出色。

So you see it's like peanut butter and jelly, And that's one of the things I love is that while used on their own, some of these are absolutely phenomenal.

但当你开始将它们组合使用，看到它们之间的协同效应，以及它们如何默契配合时，效果就完全不在一个层次上了。

But when you start stacking them together and you see the synergy and you see how they work hand in hand, it is on an entirely different level.

对我来说，KPV 是目前最被低估的多肽。

So KPV, to me, it is the most underrated peptide right now.

但越来越多的人开始了解并掌握它。

It's but more and more people are starting to get up to speed on it and understand.

在我看来，这就像下一代的 BPC，每个人都会想使用它，尤其是考虑到大家对肠漏症以及其他我提到的这些状况的日益关注。

To me, this is like the next generation BPC that everybody's gonna be wanting to use it, especially with all of the understanding and concern on leaky gut and all of these other conditions that I talked about.

我真心相信，我知道每个人都把 BPC 和 TB 500 当作他们的核心组合。

And I truly believe that I know that everybody uses BPC and TB 500 as, like, their master stack.

我认为KPV会取代TB500。

I think KPV will replace TB five hundred.

我相信它更强效。

I believe it is stronger.

它的作用更多。

It does more.

TB500与BPC-157配合使用效果极佳。

TB five hundred works extremely well with BPC-one five seven.

毫无疑问。

No doubt.

这一点毫无疑问。

There's no doubt there whatsoever.

我一直大力推崇这一点。

I've been a huge proponent of that.

但如果你必须在全部四种肽中选择，尽管我非常喜爱GHK-CU，我首选的前两种绝对是BPC-157和KPV。

But if you had to pick between all four in the close stack and as much as I love GHKCU, the the first two I would pick would be BPC-one five seven and KPV all day long.

这就是概况。

That's the synopsis there.

它比BPC-157更好吗？

Is it better than BPC-one hundred fifty seven?

这一点有争议，因为它解决了一个非常普遍的问题，我们说的是肠漏。

That's arguable considering that it addresses something that is so prevalent of a problem, and we're talking about leaky gut.

我认为这是影响整体健康恶化的主要问题之一。

I believe that is one of the biggest problems and biggest culprits in the degradation of overall health.

尽管BPC对于损伤修复和预防至关重要，但我认为肠漏是个更大的问题。

And as much as as necessary as BPC is for injury healing and prevention, I think leaky gut is a much bigger problem.

KPV有其合理的优势，但每个人的看法不同。

I think there's a fair argument there in KPV's favor, but to each their own.

我在这里只是提供事实。

I'm only here to give facts.

所以说，敬请期待更多内容。

So that being said, stay tuned for plenty more to come.

戴伦·杰梅利告别。

Dylan Gemelli signing off.